اثرات methylsulfonylmethane بر colitis تجربی در رت

امیرشاهرخی, کیوان ، بهلولی, شهاب ، چینی فروش, میرمهدی (1390) اثرات methylsulfonylmethane بر colitis تجربی در رت. Toxicology and Applied Pharmacology ــ 253 (3). ص.ص.197-202. شاپا 0041-008X

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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/article/pii/S...

عنوان انگليسي

The effect of methylsulfonylmethane on the experimental colitis in the rat

خلاصه انگلیسی

Methylsulfonylmethane (MSM), naturally occurring in green plants, fruits and vegetables, has been shown to exert anti-inflammatory and antioxidant effects. MSM is an organosulfur compound and a normal oxidative metabolite of dimethyl sulfoxide. This study was carried out to investigate the effect of MSM in a rat model of experimental colitis. Colitis was induced by intracolonic instillation of 1 ml of 5% of acetic acid. Rats were treated with MSM (400 mg/kg/day, orally) for 4 days. Animals were euthanized and distal colon evaluated histologically and biochemically. Tissue samples were used to measurement of malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), glutathione (GSH) and proinflammatory cytokine (TNF-α and IL-1β) levels. Results showed that MSM decreased macroscopic and microscopic colonic damage scores caused by administration of acetic acid. MSM treatment also significantly reduced colonic levels of MDA, MPO and IL-1β, while increased the levels of GSH and CAT compared with acetic acid-induced colitis group. It seems that MSM as a natural product may have a protective effect in an experimental ulcerative colitis.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :شهاب بهلولی
اطلاعات اضافی :Impact Factor: 3.359 Abstracting and Indexing : 1- ISI , Science Citation Index Expanded , MEDLINE ,Science Citation Index , 2-BIOSIS , Chemical Abstracts ,Current Contents (Life Sciences,EMBASE ,Scopus 3-Chemical Hazards Index , Clinical Medicine), EMBiology International Pharmaceutical Abstracts , Medical Abstracts Newsletter , Research Alert , Safety Science Abstracts , Toxicology Abstracts
کلید واژه ها:متیل سولفونیل متان ، کولیت تجربی ، التهاب ، متابولیتهای التهاب
کلید واژه ها (انگلیسی):Methylsulfonylmethane , Experimental colitis , Inflammation , Reactive oxygen metabolites
موضوعات :QV فارماکولوژی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش پاتولو‍ژي
دانشكده پزشكي > گروه علوم پایه > بخش فارماکولوژی
کد شناسایی :2400
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :09 خرداد 1390 12:09
آخرین تغییر :07 مهر 1393 06:08

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