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ظهور سویه های استافیلوکوکوس اورئوس مقاوم به پریستینا مایسین و کاهش حساسیت یافته به تئیکوپلانین در میان پرسنل پرستاری در اردبیل، ایران

ارزنلو, محسن ، جنتی, الهام ، حبیب زاده, شهرام (1390) ظهور سویه های استافیلوکوکوس اورئوس مقاوم به پریستینا مایسین و کاهش حساسیت یافته به تئیکوپلانین در میان پرسنل پرستاری در اردبیل، ایران. در: چهارمین کنگره میکروبیولوژیست های اروپا, 9-5 تیر ماه 1390, سوئیس- ژنو.

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عنوان انگليسي

Emergence of pristinamycin resistant and teicoplanin reduced susceptibility staphyloccous aureus isolates among nursing staff in Ardabil, Iran

خلاصه انگلیسی

Background and objective: Staphylococcus aureus is one of the most important cause of nosocomial infections. Emergence of Methicillin resistant Staphylococcus aureus strains (MRSA) pushed staphylococcal infections into new era of antimicrobial therapy. Microbiologically they are usually multidrug resistant strains and do not response to many conventional antibiotics that this limits proper therapeutical options against staphylococcal infections. This study was aimed to evaluate the antimicrobial resistance pattern of Staphylococcus aureus strains isolated from nursing staff in a teaching university hospital against Pristinamycin, Linozolid and Teicoplanin. Methods: This study was carried out on total 41 S.aureus strains isolated from nursing staff. Minimum inhibitory concentration (MIC) of Oxacillin to the isolates was determined by agar dilution method. At first the antibiotic sensitivity of isolates against pristinamycin, linozolid and teicoplanin were tested by the Kirby Bauer disk diffusion method and the MIC of pristinamycin and teicoplanin to resistant or susceptibility reduced strains were further determined by using E-test strips. All procedures were carried out and interpreted according to CLSI. Results: Among 41 isolates 6 (15%) were resistant to methicillin. The oxacillin MICs were >512 μg/mL for 5/6 and 4 μg/mL for 1/6 MRSA isolates. Both MSSA and MRSA isolates were sensitive against linezolid. All MSSA isolates were sensitive to teicoplanin but one (16.6%) MRSA isolate had intermediate resistance pattern for teicoplanin. The mean inhibition zone diameter of teicoplanin sensitive isolates for MRSA and MSSA were 1.48 and 1.62 mm respectively. The teicoplanin MICs against MRSA were 0.25 μg/ml for 2/6, 0.1 μg/ml for 3/6 and 0.05 μg/ml for 1/6 isolates and for selected MSSA isolates the MICs were between 0.1 to <0.001 μg/ml. 4 (11.4 %) of 35 MSSA and 5 (83.3 %) of 6 MRSA isolates were resistant against pristinomycin. The prisyinamycin MICs against MRSA were >240 μg/ml for 5/6 and 0.01 μg/ml for1/6 isolates and for MSSA (pristinamycin resistant according to disk diffusion method) were >240 μg/ml for 2/4 and 30 μg/ml for 2/4 isolates. Conclusion: These antibiotics are not used in the study setting and at all in Iran for patient management. Emergence of pristinamycin resistant and teicoplanin reduced susceptibility Staphylococcus aureus strains in the absence of antibiotic selective pressure indicate that these antibiotics can not be advocated for empirical therapy for treatment of Staphylococcal infections.

نوع سند :موضوع کنفرانس یا کارگاه (پوستر )
زبان سند : انگلیسی
نویسنده مسئول :محسن ارزنلو
کلید واژه ها:استافیلوکوکوس اورئوس ، پریستینامایسین ، تئیکوپلانین
کلید واژه ها (انگلیسی):Staphylococcus aureus , Pristinamycin , Teicoplanin
موضوعات :QW میکروب شناسی و ایمنی شناسی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی
کد شناسایی :2490
ارائه شده توسط : دکتر محسن ارزنلو
ارائه شده در تاریخ :30 تیر 1390 07:52
آخرین تغییر :29 بهمن 1391 08:19

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