title

اثر تجویز طولانی مدت متیل سولفونیل متان بر روی استرس اکسیداتیو ناشی از فعالیت ورزشی حاد در مردان سالم غیر ورزشکار

نخستین روحی, بابک ، برمکی, سارا ، خوش خواهش, فائقه ، بهلولی, شهاب (1390) اثر تجویز طولانی مدت متیل سولفونیل متان بر روی استرس اکسیداتیو ناشی از فعالیت ورزشی حاد در مردان سالم غیر ورزشکار. Journal of Pharmacy and Pharmacology ــ 63 (10). ص.ص.1290-1294. شاپا 00223573

[img]
پیش نمایش
متنی - نسخه چاپ شده
68kB
[img] متنی - نسخه چاپ شده
محدود به فقط پرسنل سامانه

456kB

آدرس اینترنتی رسمی : http://dx.doi.org/10.1111/j.2042-7158.2011.01314.x


عنوان انگليسي

Effect of chronic supplementation with methylsulfonylmethane on oxidative stress following acute exercise in untrained healthy men

خلاصه انگلیسی

Objective  This study was conducted to assess the effects of chronic daily methylsulfonylmethane (MSM) supplementation on known markers of oxidative stress following acute bouts of exercise in untrained healthy young men. Methods  Eighteen untrained men volunteered for this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (n = 9) and placebo (n = 9). The participants took supplementation or placebo daily for 10 days before running. Participants ran 14 km. The MSM supplementation was prepared in water at 50 mg/kg body weight. The placebo group received water. Serum malondialdehyde (MDA), protein carbonyl (PC) and plasma oxidized glutathione (GSSG) were measured as markers of oxidative stress. The plasma-reduced glutathione (GSH) level and the GSH/GSSG ratio were determined as markers of plasma antioxidant capacity. Key Findings  Acute exercise led to elevated levels of serum MDA, PC and plasma GSSG. MSM supplementation maintained PC, MDA and GSSG at lower levels after exercise than the placebo. The plasma level of GSH and the ratio of GSH/GSSG were significantly higher in the MSM supplemented group. Conclusions  These results suggest that chronic daily oral supplementation of MSM has alleviating effects on known markers of oxidative stress following acute bouts of exercise in healthy young men.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :بابک نخستین روحی
نویسنده مسئول :شهاب بهلولی
اطلاعات اضافی :Impact Factor: 1.918 ISI Journal Citation Reports © Ranking: 2010: 144/249 (Pharmacology & Pharmacy)
کلید واژه ها (انگلیسی):methylsulfonylmethane; antioxidant; protein carbonylation; GSH; malondialdehyde
موضوعات :QV فارماکولوژی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فارماکولوژی
کد شناسایی :2588
ارائه شده توسط : دکتر شهاب بهلولی
ارائه شده در تاریخ :26 مرداد 1390 09:15
آخرین تغییر :01 بهمن 1391 12:35

فقط پرسنل کتابخانه صفحه کنترل اسناد

Document Downloads

More statistics for this item...