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سنجش آمین اکسیداز حاوی مس در بیماران مبتلا به سرطان معده

امانی, مجتبی ، برزگر, ابوذر ، اتحاد, غلامحسین ، یزدانبد, عباس (1390) سنجش آمین اکسیداز حاوی مس در بیماران مبتلا به سرطان معده. در: دوازدهمين کنگره بيوشيمی ايران و چهارمين کنگره بين المللی بيوشيمی و بيولوژی مولکولی, 15 تا 18 شهريور 1390, ایران - مشهد.

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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/article/pii/S...


عنوان انگليسي

Evaluation of Cu containing amine oxidase is sera of gastric cancer patients

خلاصه انگلیسی

Introduction: Cupper containing amine oxidase (Cu-AO) catalyzes the deamination of primary amines to corresponding aldehydes in the presence of oxygen with the subsequent release of ammonia and hydrogen peroxide. Cu-AO also is known as soluble vascular adhesion molecule-1 (sVAP-1). It has been shown that the serum level of Cu-AO changes in various cancers. Literature review showed that there was no information on Cu-AO serum concentration among Iranians as well as in gastric cancer patients. The present study was conducted with two major aims 1) determination of Cu-AO concentration in healthy people; 2) to investigate the changes of the enzyme in gastric patients compared to control. Material and method: This investigation as a case–control study included 200 healthy and GC patient volunteers referred to Aras Clinic in Imam Khomeini Hospital. Blood samples were collected and serum was separated and stored at −70 °C until ELISA examinations. Questionnaires were distributed and filled out by both patients and healthy people. Results and conclusion: Present investigation showed that there is no significant change in serum level of Cu-AO in regard to sex, age, smoking and BMI. The serum level of Cu-AO in healthy subjects was higher than values reported in other countries. Whether these finding would open new sights into etiology of high incidence of GC in Ardabil province needs further investigations. Cu-AO levels in serum show a significant decrease in GC patients in relative to controls, this decline in Cu-AO might have been used as a biomarker for gastric cancer diagnosis.

نوع سند :موضوع کنفرانس یا کارگاه (پوستر )
زبان سند : انگلیسی
نویسنده مسئول :مجتبی امانی
اطلاعات اضافی :doi:10.1016/j.clinbiochem.2011.08.521
کلید واژه ها:سرطان معده، SSAO، بیومارکر، sVAP،
کلید واژه ها (انگلیسی):SSAO, sVAP, biomarker, gastric cancer
موضوعات :QU بیوشیمی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
دانشكده پزشكي > گروه علوم پایه > بخش بیوفیزیک
دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی
کد شناسایی :2679
ارائه شده توسط : دکتر مجتبی امانی
ارائه شده در تاریخ :11 مهر 1390 12:44
آخرین تغییر :21 فروردین 1393 07:31

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