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نقش مهار کننده گیرنده GABAA بر اثر ضد دردی مورفین در هسته میخی شکل

رضواني پور, مظفر ، حق پرست, عباس ، شیخکانلوی میلان, حمید (1385) نقش مهار کننده گیرنده GABAA بر اثر ضد دردی مورفین در هسته میخی شکل. International journal of pharmacology ــ 2 (4). ص.ص.400-405. شاپا 1811-7775

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عنوان انگليسي

The Role Of GABAA Receptor Inhibitor On Morphine Antinociception Action In Cuneiformis Nucleus

خلاصه انگلیسی

In order to investigate the role of cuneiformis (CnF) in pain modulation, we evaluated the effect of GABAA antagonist (bicuculline) on antinociceptive response of morphine in this nucleus. Eighty five male N-MRI rats, weighing 250-350 g were used, they were maintained on a 12 h light/dark cycle at 22-24°EC. The animals were anesthetized with pentobarbital sodium (60 mg kg-1 ip) and were fixed on a stereotaxic apparatus. Then CnF was calculated and the animal was left to recovery for one week. The animals were divided into 4 groups; group I which received 0.5 μL of different doses of bicuculline dissolved in saline (12.5, 25, 50 and 100 ng), group II which received morphine (10 g/0.5 μL saline), group III which received a dose of bicuculline (50 ng/0.5 μL saline) plus morphine (10 g/0.5 μL saline) that followed with receive of naloxone (2 mg kg-1, i.p.) and group IV; which received 0.5 μL saline and served as control. Tail Flick Latency (TFL) was measured as an index of pain during 2, 7, 12, 17, 22 and 27 min post micro-injection in CnF in all groups. Micro-injection of bicuculline in CnF increased TFL dose dependently. Morphine + bicuculline significantly increased maximum possible effect (%MPE) of antinociceptive response compared with morphine or bicuculline alone. Naloxone decreased the response to morphine. The results of this study indicates that CnF has a significant role in pain modulation, gabaergic system and opioid analogs have also play an important role on its antinociception.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :مظفر رضواني پور
کلید واژه ها (انگلیسی):GABAA , Morphine , Cuneiformis , Antinociception
موضوعات :QT فیزیولوژی
WL سیستم عصبی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :3396
ارائه شده توسط : دکتر حمید شیخکانلوی میلان
ارائه شده در تاریخ :01 مرداد 1391 12:30
آخرین تغییر :23 بهمن 1391 10:11

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  • نقش مهار کننده گیرنده GABAA بر اثر ضد دردی مورفین در هسته میخی شکل. (deposited 01 مرداد 1391 12:30) [Currently Displayed]

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