ارزیابی تاثیر Preconditioning مرحله ای بر فاکتورهای بیوشیمیایی در بیماران تحت عمل جراحی CABG

محمدزاده, علیرضا ، جعفری, ناصر ، باباپور, بهزاد ، دوستکامی, حسین ، حسینیان, عدالت ، حسن پور, محمد (1391) ارزیابی تاثیر Preconditioning مرحله ای بر فاکتورهای بیوشیمیایی در بیماران تحت عمل جراحی CABG. ISRN Cardiology ــ 2012 (2012). ص.ص.4-1. شاپا 2090-5599

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آدرس اینترنتی رسمی : http://www.isrn.com/journals/cardiology/

عنوان انگليسي

Effect of Staged Preconditioning on BiochemicalMarkers in the Patients Undergoing Coronary Artery Bypass Grafting

خلاصه انگلیسی

The present study has investigated the effectiveness of staged-preconditioning, in both remote and target organs. After IP the myocardial release of the biochemicalmarkers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB), cardiac troponin T (cTnT) and lactate dehydrogenase (LDH) were evaluated in patients who underwent CABG, with and without staged-preconditioning. Sixty-one patients entered the study; there were 32 patients in the staged-preconditioning group and 29 patients in the control group. All patients underwent on-pump CABG using cardiopulmonary bypass (CPB) techniques. In the staged-preconditioning group, patients underwent two stages of IP on remote (upper limb) and target organs. Each stage of preconditioning was carried out by 3 cycles of ischemia and then reperfusion. Serum levels of biochemical markers were immediately measured postoperatively at 24, 48 and 72 h. Serum CK-MB, CPK and LDH levels were significantly lower in the staged-preconditioning group than in the control group. The CK-MB release in the staged-preconditioning patients reduced by 51% in comparison with controls over 72 h after CABG. These results suggest that myocardial injury was attenuated by the effect of three rounds of both remote and target organ IP.

نوع سند :مقاله
زبان سند : انگلیسی
مجری اصلی :علیرضا محمدزاده
نویسنده مسئول :ناصر جعفری
همکار طرح :بهزاد باباپور
همکار طرح :حسین دوستکامی
همکار طرح :عدالت حسینیان
همکار طرح :محمد حسن پور
اطلاعات اضافی :Abstracting and Indexing: 2- PubMed , PubMed Central 3- Academic OneFile , Airiti Library, Chemical Abstracts CINAHL Plus,CINAHL Plus with Full Text,Directory of Open Access Journals DOAJ),EBSCO Discovery Service EBSCOhost Connection,Google Scholar,HINARI Access to Research in Health Programme,InfoTrac Custom journals J-Gate Portal
کلید واژه ها (انگلیسی):Staged Preconditioning, Biochemical Markers, Coronary artery bypass grafting
موضوعات :QU بیوشیمی
WG سیستم قلب و عروق
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
دانشكده پزشكي > گروه علوم پایه > بخش بیوشیمی
کد شناسایی :3479
ارائه شده توسط : آقای ناصر جعفری
ارائه شده در تاریخ :07 شهریور 1391 11:15
آخرین تغییر :29 آذر 1396 05:47

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