Saeed Pirouzpanah, PhD1,
Morteza Atri, MD., Prof.2, Mohammad Tabatabaiefar1, S.
Saeed Hosseini-Asl1, and Parvin Mehdipor1. (1) Department
of Medical Genetics, School of Medicine, Tehran University of Medical Sciences,
Poursina Ave., Tehran, 14155-6447, Iran, (2) Tehran University of Medical
Sciences/ Day Hospital., Cancer Institute, Gharib Ave.,, Tehran, 14155-6447,
Iran
Objective:The different germline mutations
are known to cause breast cancer (BC), which might have induced as some other
malignancies in degrees of relatives, and an increased risk of developing BC and
clinical outcomes. Therefore we aim to investigate whether the independent
familial gastric cancer (FGC) influence the survival of Iranian breast cancer
patients. Methods:Totally BC phenotype in 736 pedigrees ascertained through BC
probands with primary breast cancer. Information on FH for BC was obtained at
diagnosis by interview. Hazard ratios (HRs) and the corresponding 95% confidence
intervals (95% CIs), adjusted for confounding factors, were computed using
proportional hazard models. Results:Gastric cancer was found the most frequent
carcinoma after BC across pedigrees (13%). The probands of BC with positive FH
of BC show longer survival, compared with no-FH patients (86 vs. 69 months; Log
rank test, Chi-square= 3.8, P=0.093). The survival of probands who had 1st, 2nd,
3rd or 2nd /3rd degree of relatives included 69, 86, 90 or 63 months,
respectively (log rank test, Chi-square=3.11, P=0.048). When BC accompanied with
GC in relatives, probands with 2nd and 3rd degrees show 60 and 91 months
survival, respectively (log rank test, Chi-square=3.34, P=0.083). When
adjustment for age, site, tumor size, ER, metastasis and treatments performed
hazard ratio (HR) for poorer survival in FH positive of GC was 0.612(95%CI:
0.057-0.997). Therefore, corresponding results show that FH of gastric carcinoma
may predict the risk of survival inversely, but the closure affected degree of
relatives likely provide poorer prognosis for BC patients' survival thorough
pedigrees aggregation.
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Detection and Treatment
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Detection and Treatment
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Cancer Congress
2006