title

ژن درمانی خودکشی

حسینی اصل, سید سعید (1392) ژن درمانی خودکشی. [منابع آموزشی ]

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عنوان انگليسي

Suicide Gene Therapy

خلاصه انگلیسی

Chemotherapy is widely used with surgery and radiotherapy for the treatment of malignant disease. Selectivity of most drugs for malignant cells remains elusive. Unfortunately, an insufficient therapeutic index, a lack of specificity, and the emergence of drug-resistant cell subpopulations often hamper the efficacy of drug therapies. A number of specific difficulties are associated with the treatment of solid tumors: Access of drugs to cancer cells is often limited by poor, unequal vascularization and areas of necrosis. The histological heterogeneity of the cell population within the tumor is another major drawback. Attempts to target therapies to tumors have been addressed by using prodrugs activated in tumors by elevated selective enzymes. An alternative strategy is using antibodies to target tumors with foreign enzymes that subsequently activate prodrugs. One approach aimed at enhancing the selectivity of cancer chemotherapy for solid tumors relies on the application of gene therapy technologies. Gene therapies are techniques for modifying the cellular genome for therapeutic benefit. In cancer gene therapy, both malignant and nonmalignant cells may be suitable targets.

نوع سند :منابع آموزشی
زبان سند : انگلیسی
نویسنده :سید سعید حسینی اصل
کلید واژه ها (انگلیسی):Suicide , Gene Therapy
موضوعات :QZ آسیب شناسی
WB پزشکی عملی
WM روانپزشکی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش ژنتیک
کد شناسایی :4264
ارائه شده توسط : دکتر سید سعید حسینی اصل
ارائه شده در تاریخ :28 خرداد 1392 09:04
آخرین تغییر :28 خرداد 1392 09:04

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