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اثر متیل سولفونیل متان بر آسیب کبدی و ریوی ناشی از پاراکوات

امیرشاهرخی, کیوان ، بهلولی, شهاب (1392) اثر متیل سولفونیل متان بر آسیب کبدی و ریوی ناشی از پاراکوات. Inflammation ــ 36 (5). ص.ص.1111-1121. شاپا 0360-3997

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آدرس اینترنتی رسمی : http://link.springer.com/article/10.1007%2Fs10753-...


عنوان انگليسي

Effect of methylsulfonylmethane on paraquat-induced acute lung and liver injury in mice

خلاصه انگلیسی

Methylsulfonylmethane (MSM) is a natural organosulfur compound that exhibits antioxidative and anti-inflammatory effects. This study was carried out to investigate the effect of MSM on paraquat (PQ)-induced acute lung and liver injury in mice. A single dose of PQ (50 mg/kg, i.p.) induced acute lung and liver toxicity. Mice were treated with MSM (500 mg/kg/day, i.p.) for 5 days. At the end of the experiment animals were euthanized and lung and liver tissues were collected for histological and biochemical analysis. Tissue samples were used to determine malondialdehyde (MDA), myeloperoxidase (MPO), catalase (CAT), superoxide dismutase (SOD), glutathione (GSH) and tumor necrosis factor-α (TNF-α) levels. Blood samples were used to measure plasma alanine transaminase (ALT), γ-glutamyl transferase (GGT) and alkaline phosphatase (ALP). Histological examination indicated that MSM decreased lung and liver damage caused by paraquat. Biochemical results showed that MSM treatment significantly reduced tissue levels of MDA, MPO and TNF-α, while increased the levels of SOD, CAT and GSH compared with paraquat group. MSM treatment also significantly reduced plasma levels of ALT, GGT and ALP. These findings suggest that MSM as a natural product attenuates PQ-induced pulmonary and hepatic oxidative injury.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :شهاب بهلولی
اطلاعات اضافی :Impact Factor 2012 : 2.457 Abstracted/Indexed in: Science Citation Index, Science Citation Index Expanded (SciSearch), Journal Citation Reports/Science Edition, PubMed/Medline, SCOPUS, EMBASE, Chemical Abstracts Service (CAS), Google Scholar, EBSCO, CSA, CAB International, Academic OneFile, Biological Abstracts, BIOSIS, CAB Abstracts, Current Contents/ Life Sciences, Elsevier Biobase, EMBiology, Expanded Academic, Global Health, Health Reference Center Academic, Highbeam, Index Copernicus, INIS Atomindex, International Bibliography of Book Reviews (IBR), International Bibliography of Periodical Literature (IBZ), OCLC, SCImago, Summon by Serial Solutions
کلید واژه ها:متیل سولفونیل متان ؛ آسیب کبدی و ریوی ؛ پاراکوات
کلید واژه ها (انگلیسی):Methylsulfonylmethane ; Paraquat toxicity ; Liver injury ; Lung injury
موضوعات :QV فارماکولوژی
WF سیستم تنفسی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فارماکولوژی
کد شناسایی :4348
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :11 مهر 1392 11:10
آخرین تغییر :07 مهر 1393 06:06

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