بررسی ژنوتیپ vacA d1/-i1 هلیکوباکتر پیلوری در نواحی جغرافیایی مختلف ایران با بروز بالا و پایین

لطیفی نوید, سعید ، محمدی, شیوا ، ملکی, پریچهر ، ظهری, صابر ، یزدانبد, عباس ، سیاوشی, فریده ، مسرت, صادق (1392) بررسی ژنوتیپ vacA d1/-i1 هلیکوباکتر پیلوری در نواحی جغرافیایی مختلف ایران با بروز بالا و پایین. Archives of Iranian Medicine ــ 16 (6). ص.ص.330-337. شاپا 1029-2977

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آدرس اینترنتی رسمی : http://www.aimjournal.ir/article.aspx?id=495

عنوان انگليسي

Helicobacter pylori vacA d1/-i1 Genotypes and Geographic Differentiation between High and Low Incidence Areas of Gastric Cancer in Iran.

خلاصه انگلیسی

BACKGROUND: Helicobacter pylori (H. pylori)-specific genotypes have been closely correlated with an increased risk of gastric cancer (GC). The present study aimed to determine the distribution of H. pylori pathogenic genotypes amongst Iranians infected with strains representing European ancestry in areas with different GC incidence. METHODS: A total of 138 H. pylori isolates from ten districts in Iran were used for genotyping. RESULTS: The following genotypic frequency was observed: vacA s1 (94.9%), s2 (5.1%), m1 (24.6%), m2 (75.4%), d1 (39.9%), d2 (60.1%), i1 (40.6%), i2 (59.4%), iceA1 (76.8%), iceA2 (52.9%), iceA1/2 (29.7%), babA2 (40.6%), and cagA (65.9%). Hierarchical analyses of molecular variance (AMOVA) for the vacA d1, d2, i1, and i2 alleles and iceA1 and iceA1/2 genes found significant levels of genetic differentiation among populations (P < 0.05). Prevalence of the vacA d1, i1, and iceA1/2 (but not iceA1) genes and vacA d1/i1, vacA d1/iceA1, vacA d1/iceA1/2, vacA d1/cagA+, vacA i1/iceA1, vacA i1/iceA1/2, and vacA i1/cagA+ genotypes were significantly higher (>2- or 3-fold) among H. pylori isolates from high incidence GC areas that had age-standardized rates (ASRs) of >20/105 (max. 51.8/105) when compared with those from low incidence (ASRs <10/105) GC areas (P < 0.005, for the latter, P = 0.016). In contrast, the vacA d2/i2, m2/d2, and m2/i2 genotypes were significantly more prevalent in low compared to high incidence GC areas (P < 0.005). The results of Mantel's test only showed a low correlation between genetic and geographic distances for the iceA1 and iceA1/2 (but not vacA alleles, iceA2, babA2, and cagA) genes among ten districts of Iran (r = 0.098 and 0.074, respectively, P < 0.05). CONCLUSIONS: We propose that the H. pylori vacA d1/-i1 genotypes, which are new determinants of GC, have tremendous potential for differentiating H. pylori strains from high and low incidence GC areas in Iran

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :سعید لطیفی نوید
نویسنده :عباس یزدانبد
نویسنده مسئول :فریده سیاوشی
اطلاعات اضافی :Impact Factor: (2013)1.108 Indexed in PubMed/MEDLINE, ISI Web of Science, EMBASE, OPUS, CINHAL, PASCAL, CSA, SID
کلید واژه ها (انگلیسی):H. pylori , genotypes , gastric cancer , incidence , Iran
موضوعات :QW میکروب شناسی و ایمنی شناسی
WI سیستم گوارشی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :4360
ارائه شده توسط : دکتر شهرام حبیب زاده
ارائه شده در تاریخ :21 تیر 1392 19:19
آخرین تغییر :18 آبان 1394 08:51

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