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مقايسه اثر درماني دو داروي كرم موضعي كلوتريمازول 1% و كرم موضعي تربينافين 1% در درمان بيماران مبتلا به كچلي بدن و كچلي كشاله ران

اسدی, محمدعلی ، طلایی, رضوان ، رایگان, فریبا ، غنی, حسین ، صامعی, اعظم (1391) مقايسه اثر درماني دو داروي كرم موضعي كلوتريمازول 1% و كرم موضعي تربينافين 1% در درمان بيماران مبتلا به كچلي بدن و كچلي كشاله ران. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

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عنوان انگليسي

Comparing the Therapeutic Effect of Clotrimazole 1% Local Cream and Terbinafine Local Cream in Treating of Patients Given to Tinea Corporis and Tinea Cruris

خلاصه انگلیسی

Backgrund & Objectives: Tinea corporis is dermatophytosis infection of skin without hair and Tineacruris, is in fact a type of Tinea corporis .The usual treatment of this two disease, involves the topical application of azoles and allylamines. this study attempts to identify drug that has the most cost- benefit efficacy in between two topical creams ofTerbinafine 1% and Clotrimazole 1%. Methods: Afterward that with preparated smir with positive KOH, dermatophytosis of 100patients with suspicious to Tinea corporis and 50 patients with suspicious to Tinea cruris referred to the Kashan reference laboratory was determined, a portion of culture on SCC medium, is prescripted one of two drugs of terbinafine 1% or clotrimazole 1% local cream, randomly and single blind, twice daily for 2 weeks and providing of requirement 4 weeks; after than 2 and 4 weeks treatment, result of improvement was checked of clinical and laboratory (smir and culture) aspect. Results: In this study, cure rate of Terbinafine to compared with clotrimazole in treatment oftinea corporis and tinea cruris, after 2 weeks treatment, was respectively, 69/3% versus 77.3%with P=0.505. and after 4 weeks treatment (providing of requirement), was respectively, 78.3%versus 70.6% with P=0.849; Also cure rate of Terbinafine to compared with clotrimazole intreatment of tinea corporis, after 2 weeks treatment, was respectively, 64% versus 76% with P=0.432. and after 4 weeks treatment (providing of requirement), was respectively, 72.2% versus 58.3% with P=0.837; Also cure rate of Terbinafine as compared to clotrimazole in treatment of tinea cruris, after 2 weeks treatment, per two groups of therapeutic, was 80% with P=N.S. and after 4 weeks treatment (providing of requirement), per two groups of therapeutic, was 100% with P=N.S. In this study, teminafine afid clotrimazole were significantly effectived in treatment of Trichophyton. mentagrophytes, Trichophytonverrucosum,Trichophytonrubrumand Epidermophytonfloccosum with statistical aspect (P<0.05) but .alone trebinafine were significantly effectived in treatment of Trichophyton rubrum and Microsporum canis with statistical aspect (P<0.03). In sum, among of therapeutic groups is not observed no differentiation in age, sex, occupation,duration of sickness, history of contact with the animal, type of lesion, clinical symptoms,diameter, number and type of fungus (P<0.05). Conclusion: Since there was no statistically significant difference in cure rate,lack of side affect due to two drugs of terbinafine and clotrimazole and more expensive of terbinafine than clotrimazole however clotrimazole can be Spotted as a good option in treatment of tinea corporis and or cruris, although prescription of type and form of medication has dependent to patient's acceptation and tolerance but no physical and mycological features.

نوع سند :موضوع کنفرانس یا کارگاه (پوستر )
زبان سند : انگلیسی
نویسنده مسئول :محمدعلی اسدی
کلید واژه ها (انگلیسی):Tinea Corporis ; Tinea Cruris ; Terbinafine 1% Local Cream ; Clotrimazole 1% Local Cream
موضوعات :QV فارماکولوژی
QW میکروب شناسی و ایمنی شناسی
WR بیماریهای پوست
بخش های دانشگاهی :معاونت تحقیقات و فناوری > مديريت تحقیقات و فناوری و اطلاع رساني > مدیریت همایش ها و کنگره های دانشگاه
کد شناسایی :4720
ارائه شده توسط : خانم صغری گلمغانی
ارائه شده در تاریخ :09 مهر 1392 08:29
آخرین تغییر :09 مهر 1392 08:29

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