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مقایسه اثر کلوفیبرات با فنوباربیتال در کاهش ایکتر نوزادی

احدی, عادل ، میرزا رحیمی, مهرداد ، احمدآبادی, فرزاد ، توسلی, علیرضا ، پروانه, ن (1392) مقایسه اثر کلوفیبرات با فنوباربیتال در کاهش ایکتر نوزادی. Iranian Journal of Neonatology ــ 4 (3). ص.ص.13-19. شاپا 2251-7510

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عنوان انگليسي

Comparison of the efficacy of Clofibrate with Phenobarbital in decreasing neonatal hyperbilirubinemia

خلاصه انگلیسی

Background: Hyperbilirubinemia is a common problem in newborn infants. It can progress to kernicterus in severe forms, unless an intervention is initiated. The objective of this study was to Compare the efficacy of Clofibrate with Phenobarbital in full-term neonates with nonhemolytic jaundice. Methods: this double blind clinical trial study was performed on 60 neonate that divided randomly two groups of full-term jaundiced neonates: the clofibrate-treated group (n = 30) and the Phenobarbital group (n = 30). Infants in the clofibrate group received a single oral dose of 100 mg/kg clofibrate while the neonates in the Phenobarbital group received a single oral dose of 5 mg/kg Phenobarbital; both groups received phototherapy. Serum total and direct bilirubin levels were measured at the beginning, 12 and 24 hours, after the start of the trial. Results: The mean ± SD total serum bilirubin level of the Phenobarbital group and clofibrate groups at enrollment was 17.84 ± 1.017 and 18.04 ±0.852 mg/dL, respectively. The mean ± SD total serum bilirubin in Phenobarbital group and clofibrate groups after 24 hours was 11.11 ± 1.273 and 12.55 ± 1.008 mg/dL, respectively (P = 0.000). After 72 hours of intervention, 25 (83%) neonates of the Phenobarbital group and 23 (76%) of the clofibrate group were discharged with a total serum bilirubin of <10 mg/dL (P = 0.000). No side-effect was observed on serial examination during hospitalization, and on the first and seventh day after discharge. Conclusion: Phenobarbital in the compared with clofibrate results in a faster decline in TSB, shorter duration of hospitalization and had no side effects in jaundiced full-term neonates.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :عادل احدی
نویسنده مسئول :مهرداد میرزا رحیمی
نویسنده :فرزاد احمدآبادی
نویسنده :علیرضا توسلی
نویسنده :ن پروانه
اطلاعات اضافی :Indexed in: PubMed/Pubmed Central , EMBASE , Scopus , ISC(Islamic World Science Citation Center) , CABI(Bibliographic database) , IMEMR (Index Medicus for Eastern Mediterranean Region) , Index Copernicus , EBSCO (CINAHL), Proquest (CSA: In Neuroscience Database) , DOAJ , Google scholar , SID(Scientific Information Database) , Iranmedex , Magiran , IranJournal (RiceSt
کلید واژه ها (انگلیسی):clofibrate , Phenobarbital , hyperbillirubinemia , neonatal jaundice
موضوعات :WH سیستم های خونی و لنغاوی
WI سیستم گوارشی
WS بیماریهای کودکان
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
کد شناسایی :4795
ارائه شده توسط : دکتر عادل احدی
ارائه شده در تاریخ :28 مهر 1392 12:27
آخرین تغییر :13 اردبهشت 1394 09:32

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