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بررسی شیوع میکروبی و مقاومت آنتی بیوتیکی در بیماران فیبروز کیستی در تهران

اکبری, رضا ، والی, پریسا ، سیف پور, مریم ، شاهچراغی, فرشته (1391) بررسی شیوع میکروبی و مقاومت آنتی بیوتیکی در بیماران فیبروز کیستی در تهران. در: The 13th Iranian & The Second International Congress of Microbiology, July 14 – 16, 2012, Ardabil - Iran.

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عنوان انگليسي

Survey of Microbial Prevalence and Antibiotic Resistance in Cystic Fibrosis Patients in Tehran

خلاصه انگلیسی

Background & Objectives: Cystic fibrosis is the most common lethal genetic disease in white populations. Cystic fibrosis is caused by a mutation in a gene that encodes cystic fibrosis transmembrane conductance regulator (CFTR) protein,which is expressed in many epithelial cells and blood cells. Respiratory tract of Cystic fibrosis patients can be described as natural environments harbouring persisting microbs such as Pseudomonas aeruginosa, Burkholderia cepacia, Achromobacter xylosoxidans, and Stenotrophomonas maltophilia, S. aureus, Streptococcus pneumoniae and Haemophilus influenzae.Without antibiotic treatment the patients with CF are at risk of early infection and inflammation becoming established and ultimately progressing to fatal respiratory failure. The goal of this study was to examine the current microbiology and susceptibility of organisms isolated from Cystic fibrosis patients. Methods: Sputum samples cultured on Blood agar,B. cepacia selective agar (BCSA), MacConkey's Agar, Cetrimide agar and Chocolate agar. Isolates was detected by conventional microbial methods. Then antibiotic susceptibility of isolates detected by Kirby-Bauer disk diffusion methods and serial microdilution (MIC) methods. Results: In this study 24 sputum samples of cystic fibrosis patients examined.18 patients infectd with bacteria as Enterococcus faecium (n=1), Enterobacter agglomerans(n=1), Enterobacter cloacae(n=2), E.coli (n=2), Pseudomonas aeruginosa (n=1), Acinetobacter johnsonii (n=1), Acinetobacter lwoffii (n=1), Acinetobacter baumannii(n=1), Staphylococcus aureus(n=1), Staphylococcus lugdunensis(n=1), Staphylococcus schleiferi(n=1), Stenotrophomonas maltophilia (n=1), Klebsiella pneumoniae (n=2), Moraxella osloensis (n=1), Moraxella atlantae(n=1). In some patients more than one bacteria isolated. E.faecium is the most resistant to all group of antibiotics.The most antibiotic resistancy is relate to cephalosporins, Penicillin and Nitrofurantoin and the least of antibiotic resistancy is relate to meropenem and imipenem. Conclusion: Our study showed that cystic fibrosis patients in Tehran are in subject to various bacteria of gram-positive and gram-negative.Current antibiotics are not usefull in eradication of bacteria involved in cystic fibrosis patients,so usage of newer antibiotics or another technics are essential.

نوع سند :موضوع کنفرانس یا کارگاه (پوستر )
زبان سند : انگلیسی
نویسنده مسئول :رضا اکبری
کلید واژه ها (انگلیسی):Microbial Prevalence ; Antibiotic Resistance ; Cystic Fibrosis
موضوعات :QW میکروب شناسی و ایمنی شناسی
WF سیستم تنفسی
بخش های دانشگاهی :معاونت تحقیقات و فناوری > مديريت تحقیقات و فناوری و اطلاع رساني > مدیریت همایش ها و کنگره های دانشگاه
کد شناسایی :4838
ارائه شده توسط : خانم صغری گلمغانی
ارائه شده در تاریخ :01 آبان 1392 14:26
آخرین تغییر :01 آبان 1392 14:26

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