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اثر درمانی سیر (Allium sativa) در مقابل عفونت سوختگی ناشی از سودوموناس آئروژینوزا

ارزنلو, محسن ، عرب, روح اله ، علايی, رضا (1386) اثر درمانی سیر (Allium sativa) در مقابل عفونت سوختگی ناشی از سودوموناس آئروژینوزا. Research Journal of Biological Sciences ــ 2 (6). ص.ص.634-638. شاپا 1815-8846

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عنوان انگليسي

Therapeutic Efficacy of Garlic () Against Burn Wound Infection by Pseudomonas aeruginosa

خلاصه انگلیسی

Research Journal of Biological Sciences 2 (6): 634-638, 2007 Treatment of multi-drug resistant Pseudomonas aeruginosa, which causes burn infection is a big challenge in clinics and needs novel strategies. Garlic extract has potent in vitro antibacterial activities against number of gram negative and gram positive bacteria including P. aeruginosa. The aim of this study, was to evaluate in vivo therapeutic efficacy of garlic extract in treating burn wound infection caused by P. aeruginosa in burned mouse model. Burn was induced on the back of anesthetized animals by hot water, after the hair removal. Bacterial infection was established by topical applying of highly pathogenic clinical isolate of P. aeruginosa. Potential of garlic extract on reduction of mortality was evaluated by topical application of 10% (v/v) garlic extract on burned and infected animals (treatment group 1) and was compared with two control groups: Burned and infected animals either treated with topical Silver Sulphadiazine (SSD) (1%) (treatment group 2) or left untreated (treatment group 3). The same groups were subjected to evaluate bacterial counts in organs (blood, liver, spleen and skin). Our results indicated that topical administration of garlic extract (10%) extended the survival of mice for 3-6 days, compared with survival of the untreated group. Both garlic extract and SSD treatments reduced the microbial loads in vital organs (blood, liver, spleen), compared to that of untreated control group (p< 0.05). These results demonstrate the potential of garlic extract in the treatment of burn wound infection caused by P. aeruginosa.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :محسن ارزنلو
اطلاعات اضافی :Index abstract: 3- DOAJ, IndexCopernicus , Zoological Record
کلید واژه ها:سودوموناس آئروژینوزا ، عفونت سوختگی ، سولفودیازین نقره ، عصاره سیر
کلید واژه ها (انگلیسی):Pseudomonas aeruginosa , burn infection , silver sulphadiazine , garlic extract
موضوعات :QV فارماکولوژی
QW میکروب شناسی و ایمنی شناسی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش میکروبیولوژی
کد شناسایی :531
ارائه شده توسط : دکتر محسن ارزنلو
ارائه شده در تاریخ :23 آذر 1388 07:52
آخرین تغییر :18 بهمن 1391 14:11

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