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ارزیابی اثرات اضافه کردن کتامین به مرفین در بیدردی وریدی با کنترل بیمار بعد از جراحی ارتوپدی

اخوان اکبری, قدرت ، محمدیان اردی, علی ، انتظاری, مسعود (1392) ارزیابی اثرات اضافه کردن کتامین به مرفین در بیدردی وریدی با کنترل بیمار بعد از جراحی ارتوپدی. Perspectives in Clinical Research ــ 5 (2). ص.ص.85-87. شاپا 2229-3485

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عنوان انگليسي

Evaluation the effects of adding ketamine to morphine in intravenous patient-controlled analgesia after orthopedic surgery

خلاصه انگلیسی

Background: Intravenous patient-controlled analgesia (PCA) with morphine is commonly used for post-operative pain after major surgery. Ketamine has analgesic property at lower doses, and in combination with opioids it could have synergistic effect. The aim of this study is to determine effects of the addition of ketamine to morphine for PCA after orthopedic surgery. Materials and Methods: In this double-blind randomized clinical trial, 60 patients were randomly allocated to receive PCA consisting: Group 1 (morphine 0.2 mg/ml), Group 2 (morphine 0.2 mg/ml + ketamine 1 mg/ml), and Group 3 (morphine 0.1 mg/ml + ketamine 2 mg/ml). In this, anesthesiologists managed study, patients had orthopedic surgery. Assessments were made at 24 h and 48 h post-operatively. Visual analog scale (VAS) was used for recording pain score. PCA morphine use was recorded at 24 h and 48 h. VAS scores over 48 h were analyzed with analysis of variance for repeated measures. Significance level was taken as 0.05. Results: There is no significant difference between demographic information of the three groups ( P > 0.05). Control of pain in Group 2 and Group 3 was better than in Group 1 (only morphine) ( P = 0.001) but there was no significant difference between Group 2 and Group 3 ( P > 0.05). Rate of narcotic consumption in groups 2 and 3 was significantly lower than Group 1 ( P < 0.05). Conclusion: After orthopedic surgery, the addition of ketamine to morphine for intravenous PCA was superior to Intravenous PCA opioid alone. The combination induces a significant reduction in pain score and cumulative morphine consumption.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :قدرت اخوان اکبری
نویسنده مسئول :علی محمدیان اردی
نویسنده :مسعود انتظاری
اطلاعات اضافی :Indexing : PubMed , Pubmed Central, Caspur, CNKI (China National Knowledge Infrastructure), EBSCO Publishing's Electronic Databases, Expanded Academic ASAP, Genamics JournalSeek, Google Scholar, Health & Wellness Research Center, Health Reference Center Academic, Hinari, Index Copernicus, Indian Science Abstracts, National Science Library, OpenJGate, PrimoCentral, ProQuest, SCOLOAR, SIIC databases, Summon by Serial Solutions and Ulrich's International Periodical Directory
کلید واژه ها (انگلیسی):Intravenous patient-controlled analgesia , ketamine , morphine , orthopedic surgery
موضوعات :QV فارماکولوژی
WO جراحی
بخش های دانشگاهی :دانشكده پزشكي > گروه بیهوشی، زنان و زایمان
کد شناسایی :5432
ارائه شده توسط : دکتر مسعود انتظاری اصل
ارائه شده در تاریخ :12 اسفند 1392 12:07
آخرین تغییر :10 فروردین 1393 09:03

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