title

تعیین مولکولی جهش مدیترانه (G6PD) در شمال غرب ایران

ولیزاده, مهدی ، عنصری, حبیب ، فتحی, افشین ، جبارپوربنیادی, مرتضی ، رضامند, عظیم ، امانی, فیروز (1393) تعیین مولکولی جهش مدیترانه (G6PD) در شمال غرب ایران. Journal of Physiology and Pharmacology Advances ــ 4 (7). ص.ص.389-395. شاپا 2251-7693

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عنوان انگليسی

Molecular Identification of Mediterranean Mutation in Patients with Deficiency of Glucose-6-Phosphate Dehydrogenase (G6pd) in North West of Iran

خلاصه انگلیسی

Glucose-6-phosphate dehydrogenase (G6PD) is a highly polymorphic enzyme that is encoded by human X-linked gene.G6PD deficiency is the most common enzymopathy in human with approximately 400 million people affected worldwide. According to the previous studies, Mediterranean mutation (C563T) is one of the most common G6PD enzyme mutations in Iranian population with a prevalence range of %63 to %86/4.This study was conducted in order to determine Mediterranean mutation, through molecular method ,in the population of the North-west of Iran. In this study, by Rapid Genomic DNA Extraction (RGDE) method, from 77 blood samples of unrelated male and female patients with genetic deficiency of G6PD, DNA was extracted and after digestion by MboII enzymes, in order to search for Mediterranean mutation, they were analyzed by means of PCR-RFLP and sequencing methods.Of the 77 patients, 48 patients (37 male, 11 female) had a Mediterranean mutation frequency of 62/3 %. 29 patients (37/7%) had mutations other than Mediterranean type.This study revealed that G6PD is the most common mutation in Iranian North-west population. Further studies are recommended to identify the mutation type of other varieties.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :مهدی ولیزاده
نویسنده مسئول :حبیب عنصری
نویسنده :افشین فتحی
نویسنده :فیروز امانی
ضریب تاثیر و نمایه مجلات:Indexing: DOAJ, Chemical Abstract Service (CAS), Google Scholar, Open J-Gate, ScopeMed, Scientific Publications Index, Scientific Resources Database, Recent Science Index, Scholarly Journals Index, Directory of Academic Resources, Elite Scientific Journals Archive, Current Index to Scholarly Journals, Digital Journals Database, Academic Papers Database, Contemporary Research Index, Index Copernicus.
کلیدواژه ها (انگلیسی):Glucose-6-phosphate dehydrogenase, mediterranean mutation, north- west of Iran
موضوعات :WA بهداشت عمومي > WA. 900 آمار حياتي
WA بهداشت عمومي > WA. 900 آمار حياتي

QU بیوشیمی
QW میکروب شناسی و ایمنی شناسی
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
دانشكده پزشكي > گروه علوم پایه > بخش آمار حياتي
کد شناسایی :5886
ارائه شده توسط : دکتر فیروز امانی
ارائه شده در تاریخ :01 شهریور 1393 04:30
آخرین تغییر :01 شهریور 1393 04:30

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