ارتباط بین سطح مارکرالتهابی hs-CRP با شدت بیماری در بیماران با بیماری انسدادی مزمن راههای هوایی پایدار

قبادی مراللو, حسن ، فولادی, نسرین ، بیوک آقازاده, کاترین ، انصارین, خلیل (1394) ارتباط بین سطح مارکرالتهابی hs-CRP با شدت بیماری در بیماران با بیماری انسدادی مزمن راههای هوایی پایدار. Tanaffos ــ 14 (1). ص.ص.34-41. شاپا 0344-1735

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عنوان انگليسي

Association of High Sensitive CRP Level and COPD Assessment Test Scores with Clinically Important Predictive Outcomes in Stable COPD Patients

خلاصه انگلیسی

Background: High sensitive CRP (hs-CRP) is used as a marker of systemic inflammation in chronic obstructive pulmonary disease (COPD). However, we hypothesize that the raised hs-CRP is not closely related to the multiple consequences of COPD. This study was undertaken to investigate the association of COPD assessment test (CAT) score with SpO2, FEV1, body mass index (BMI), obstruction, dyspnea and exercise capacity (BODE) index and COPD exacerbation rate and compare it with the association to serum hs-CRP level. Materials and Methods: Sixty patients with stable COPD referred to the pulmonology clinic of Ardabil Imam Khomeini Hospital were included in this study. SpO2, 6-minute walk distance (6MWD), body mass index, BODE index, and pulmonary function test as well as exacerbation rate were determined in COPD patients. Then, the CAT questionnaire was completed by patients. Serum level of hs-CRP was measured in all patients and 15 controls. We statistically compared the relationships and correlations among the variables. Results: Hs-CRP level was significantly raised in patients (P=0.005). In these patients, the correlation of hs-CRP level with BODE index was significant (P=0.008). However, the correlation of hs-CRP with SpO2 and FEV1 was not significant (P=0.47 and P=0.17, respectively). Also, the correlation of CAT score with SpO2, FEV1, BODE index, and exacerbation rate in the previous year was significant (P<0.001, P<0.001, P<0.001 and P=0.017, respectively). Conclusion: SpO2, FEV1, BODE index and exacerbation rate are more correlated with CAT scores than with the serum level of hs-CRP in stable COPD patients. The findings of this study should be considered in management of stable COPD patients.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :حسن قبادی مراللو
نویسنده مسئول :نسرین فولادی
نویسنده :کاترین بیوک آقازاده
نویسنده :خلیل انصارین
اطلاعات اضافی :Indexing in: Pubmed(PMC), SCOPUS, Embase, Index Copernicus, Google Scholar, EMRO, DOAJ, Scientific Information Database SID, CABI, Electronic Journal Library, ISC
کلید واژه ها (انگلیسی):C-Reactive Protein, BODE index, COPD, hs-CRP, COPD assessment test
موضوعات :WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :6827
ارائه شده توسط : دکتر نسرین فولادی
ارائه شده در تاریخ :03 مرداد 1394 05:39
آخرین تغییر :30 آذر 1394 07:05

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