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سطح پروتئین HS-CRP دربیماران ایرانی با عوارض ریوی ناشی از گاز خردل و ارتباط آن با شدت بیماری راه هوائی

عطاران, داود ، محمدزاده لاری, شهرزاد ، خواجه دلوئی, محمد ، آیت اللهی, حسین ، توحیدی, محمد ، اثنی عشری, امیر ، قبادی مراللو, حسن ، مظلومی, مریم ، بلالی مد, مهدی (1388) سطح پروتئین HS-CRP دربیماران ایرانی با عوارض ریوی ناشی از گاز خردل و ارتباط آن با شدت بیماری راه هوائی. Human and Experimental Toxicology ــ 28 (12). ص.ص.745-739. شاپا 0960-3271

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آدرس اینترنتی رسمی : http://het.sagepub.com/content/vol28/issue12


عنوان انگليسي

Highly sensitive C-reactive protein levels in Iranian patients with pulmonary complication of sulfur mustard poisoning and its correlation with severity of airway diseases

خلاصه انگلیسی

Background: Sulfur mustard (SM) is a chemical warfare agent that can cause serious pulmonary complications. This study was designed to determine serum highly sensitive C-reactive protein (hs-CRP) and evaluate its correlation with lung function parameters in patients with chronic obstructive pulmonary disease (COPD) due to SM poisoning. Methods: Fifty consecutive SM patients with stable COPD and a mean age 46.3 + 9.18 years were enrolled in this cross sectional study. Thirty healthymen were selected as controls. Lung function parameters were evaluated. Serum hs-CRP by immunoturbidometry assay was measured in both the patients and controls. Results: In the case group, the mean forced expiratory volume in one second (FEV1) was 2.14 + 0.76 L (58.98%+17.51% predicted). The mean serum hs-CRP was 9.4+6.78 SD and 3.9+1.92 SDmg/L in the cases and controls, respectively, with significant statistical differences (p < .001). There was negative correlation between the serum hs-CRP and FEV1 levels (p ¼ .01). The serum hs-CRP levels were also correlated with Global Initiative for ChronicObstructive Lung disease (GOLD) stages (r ¼ .45, p < .001). Conclusions:Our findings suggest that the serum hs-CRP level is increased in SM patients with COPD and may have a direct correlation with disease severity. It may then be used as a marker for the severity of COPD in patients with SM poisoning.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :داود عطاران
نویسنده مسئول :شهرزاد محمدزاده لاری
اطلاعات اضافی :Impact factor:1.456 Indexing: Science Citation Index , Science Citation Index Expanded , MEDLINE /PubMed , Scopus , Academic Search Premier , Biological Abstracts , BIOSIS database , BIOSIS Previews , Chemical Abstracts Service (CAS), Chimica , Current Citations , Current Contents / Life Sciences , , Elsevier BIOBASE/Current Awareness in Biological Sciences , EMBASE/Excerpta Medica , Index Medicus , Index Veterinarius , Medical Documentation Service , Neurosciences Abstracts , Nutrition Abstracts & Review Series A: Human & Experimental
کلید واژه ها (انگلیسی):chemical warfare agents, sulfur mustard gas, veterans, chronic obstructive pulmonary disease, highly sensitive C-reactive protein
موضوعات :WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :819
ارائه شده توسط : دکتر حسن قبادی
ارائه شده در تاریخ :02 اسفند 1388
آخرین تغییر :05 فروردین 1393 10:03

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