title

تاثیر درمان با هپارین وریدی بر بیماران سکته مغزی در حال پیشرفت

قندهاری, کاویان ، نیک خواه, کریم ، برومند, امیررضا ، حسینی نژاد, سید جواد ، درخشان, سیاوش ، ملت اردکانی, علی ، فتاح زاده اردلانی, قاسم (1388) تاثیر درمان با هپارین وریدی بر بیماران سکته مغزی در حال پیشرفت. Iranian Journal of Neurology ــ 8 (28). ص.ص.637-644. شاپا 2008-384X

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عنوان انگليسي

INFLUENCE OF INTRAVENOUS HEPARIN THERAPY IN PATIENTS WITH PROGRESSIVE STROKE AND CRESCENDO TRANSIENT ISCHEMIC ATTACKS

خلاصه انگلیسی

Introduction: Progressing stroke (PS) and Crescendo Transient Ischemic Attacks (CTIA) are generally accepted, though unproven, indications for urgent anticoagulation and there remains evidence-free practice of intravenous heparin therapy in these patients. Methods and Materials: Consecutive PS and CTIA patients admitted in Mashhad Ghaem hospital during 2007-2008, enrolled in a prospective observational study. PS and CTIA patients underwent intravenous heparin therapy 1000 units per hour for 3 days without bolus dose. PS and CTIA patients who had a contraindication of intravenous heparin therapy received 80 mg Aspirin per day. Early clinical courses including improvement, stabilization, deterioration and development of residual stroke were evaluated in two therapeutic groups of PS and CTIA patients. Results: 170 PS patients (103 males, 67 females) with mean age 60.4±12.3 years and 88 CTIA patients (50 males, 38 females) with mean age 60.1±6.8 years were investigated. 141 PS and 64 CTIA patients received a short period of intravenous heparinization. The distribution of subtypes of early clinical course into two therapeutic groups of PS and CTIA patients was significantly different; X2=10.487, df=2, p=0.005 and X2=6.72, df=2, p=0.035 respectively. Distribution of residual stroke in two therapeutic groups of PS and CTIA patients was not significantly different; X2=1.443, df=1, p=0.23, OR=0.557 (0.212-1.462) and X2=1.01, df=1, p=0.315, OR=0.617 (0.24-1.587) respectively. Conclusion: PS and CTIA patients who received a short period of intravenous heparin therapy have significantly more probability of improvement and less probability of deterioration in their early clinical course.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :کاویان قندهاری
نویسنده :قاسم فتاح زاده اردلانی
اطلاعات اضافی :Indexed in: DOAJ, Academic Keys, DRJI, Google Scholar, ISC, SID, Ulrichsweb Global Serials Directory, WorldCat.
کلید واژه ها (انگلیسی):Progressive Stroke, Transient, Ischemic, Attacks, Heparin
موضوعات :WL سیستم عصبی
بخش های دانشگاهی :دانشكده پزشكي > گروه جراحی
کد شناسایی :8461
ارائه شده توسط : دکتر فیروز امانی
ارائه شده در تاریخ :05 بهمن 1395 07:52
آخرین تغییر :05 بهمن 1395 07:52

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