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تاثیر ایتکوباسیون اپی تلیوم و ایزوپرنالین بر روی پاسخ دهی تراشه خوکچه هندی نسبت به متاکولین

بسکابادی, محمد حسین ، اصلانی, محمدرضا ، طباطبایی, ای (1384) تاثیر ایتکوباسیون اپی تلیوم و ایزوپرنالین بر روی پاسخ دهی تراشه خوکچه هندی نسبت به متاکولین. Pharmacology ــ 76 (1). ص.ص.1-7. شاپا 0031-7012

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آدرس اینترنتی رسمی : https://www.karger.com/Article/Abstract/88739


عنوان انگليسي

Influence of Epithelium and Isoprenaline Incubation on Responsiveness of Guinea-Pig Trachea to Methacholine

خلاصه انگلیسی

There are reports regarding harmful effect of long-term use of β2 -agonist drugs on asthma severity and airway responsiveness. In the present study, the responses of guinea pig trachea with intact and denuded epithelium (groups 1 and 2, n = 10) to methacholine as EC50 were measured in tissues nonincubated or incubated with 10 µmol/l isoprenaline during the resting period. The same protocol was performed in groups 3 and 4 (n = 5 for each group) with an additional 30 min rest time after isoprenaline incubation. The response of trachea with denuded epithelium (groups 2 and 4) to methacholine was significantly higher than that with intact epithelium both in incubated and nonincubated conditions (groups 1 and 3, p<0.05 to p < 0.001). Incubation with isoprenaline caused a significant reduction in the tracheal response to methacholine in both the denuded groups (p<0.005 and p<0.001) and intact epithelium groups (p<0.005 for both cases). The reduction in tracheal responsiveness to methacholine due to incubation in epithelium denuded trachea (groups 2 and 4) was non significantly greater than that of intact epithelium tissues. There was no difference between groups 3 and 4 with those of groups 1 and 2 in both incubated and non incubated conditions. The maximum contractility response to methacholine was not different between tracheal chains with denuded and intact epithelium and did not change due to incubation with isoprenaline. The results of this study indicate reduction of tracheal response to methacholine due to incubation of tissues with isoprenaline, which was relatively more pronounced in epithelium denuded trachea.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :محمد حسین بسکابادی
نویسنده :محمدرضا اصلانی
اطلاعات اضافی :Impact Factor (2006) 1.240 Indexed in: ISI, Pubmed/Medline/Index Medicus, scopus,Chemical Abstracts Service, Current Contents - Life Sciences, BIOSIS Previews , Google Scholar , CAB Abstracts , Embase,
کلید واژه ها (انگلیسی):Epithelium , Adrenergic receptors , Asthma , Airway responsiveness , Desensitization
موضوعات :QT فیزیولوژی
QV فارماکولوژی
WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :8812
ارائه شده توسط : دکتر محمد رضا اصلانی
ارائه شده در تاریخ :28 مرداد 1396 05:11
آخرین تغییر :28 مرداد 1396 05:11

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