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پاسخ دهی تراشه به ایزوپرنالین و مهار کننده گیرنده آدرنرژیکی بتا- دو در خوکچه های هندی حساس شده و در معرض دود سیگار

بسکابادی, محمد حسین ، کیانی, سارا ، اصلانی, محمدرضا (1385) پاسخ دهی تراشه به ایزوپرنالین و مهار کننده گیرنده آدرنرژیکی بتا- دو در خوکچه های هندی حساس شده و در معرض دود سیگار. Respirology ــ 11 (5). ص.ص.572-578. شاپا 1440-1843

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آدرس اینترنتی رسمی : http://onlinelibrary.wiley.com/doi/10.1111/j.1440-...


عنوان انگليسي

Tracheal responsiveness to both isoprenaline and beta2-adrenoreceptor blockade by propranolol in cigarette smoke exposed and sensitized guinea pigs

خلاصه انگلیسی

Objective: Airway hyperresponsiveness is the main feature of asthma and also exists in cigarette smokers. In previous studies we have shown increased airway responsiveness to isoprenaline in asthmatic patients and smokers. In this study, tracheal responsiveness to isoprenaline and β-adrenergic receptor blockade was investigated in animals exposed to cigarette smoke (AECS) with or without sensitization by ovalbumin (OA). Methodology: Guinea pigs were exposed to cigarette smoke over a 3-month period with or without sensitization by injection and inhalation of OA. Tracheal responses in AECS, AECS + sensitized and control animals (n = 7 for each group) to isoprenaline in the absence and presence of 20 nmol/L propranolol were measured and EC50 was established. The propranolol blockade (concentration ratio minus one (CR-1)) was calculated (post-propranolol EC50/EC50) − 1. Results: The tracheal response of AECS and AECS + sensitized guinea pigs to isoprenaline was significantly higher than that of control animals (EC50: 4.24 ± 0.54, 3.66 ± 0.53 and 7.71 ± 0.68.79 μmol for AECS, AECS + sensitized and control animals, respectively) (P < 0.001). There was no significant difference in EC50 between AECS and AECS + sensitized. CR-1 was also significantly higher in the trachea of AECS and AECS + sensitized compared with controls (13.39 ± 2.22 and 15.35 ± 2.95 vs. 3.10 ± 0.6, P < 0.05 in both cases). There was no significant difference in CR-1 between AECS and AECS + sensitized. There was a significant correlation between the tracheal response to isoprenaline (EC50) and CR-1 (r = −0.731, P < 0.001). There was no significant difference in tracheal maximum response to isoprenaline between the three groups of animals. Conclusions: The results of this study indicate an increased tracheal response to a β2-adrenergic stimulating drug and enhanced β2-adrenergic blockade by propranolol in both AECS and AECS + sensitized. These results suggest similar increase in airway responsiveness to β2-adrenergic agonists and β2-receptor blockade in AECS and AECS + sensitized guinea pigs.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :محمد حسین بسکابادی
نویسنده :سارا کیانی
نویسنده :محمدرضا اصلانی
اطلاعات اضافی :Impact Factor (2006) 1.518 Indexed in ISI, Pubmed/Medline/Index Medicus, Abstracts in Anthropology (Sage) , Abstracts on Hygiene & Communicable Diseases (CABI),Academic Search (EBSCO Publishing) , Current Contents: Clinical Medicine (Clarivate Analytics) , Embase, Poultry Abstracts, Protozoological Abstracts , Review of Aromatic & Medicinal Plants
کلید واژه ها (انگلیسی):beta2-adrenoreceptor blockade, COPD, guinea pig, tracheal responsiveness
موضوعات :QT فیزیولوژی
QV فارماکولوژی
WF سیستم تنفسی
بخش های دانشگاهی :دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی
کد شناسایی :8819
ارائه شده توسط : دکتر محمد رضا اصلانی
ارائه شده در تاریخ :24 تیر 1396 08:36
آخرین تغییر :24 تیر 1396 08:36

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