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Methylsulfonylmethane در مقابل آسیب موکوس معده موثر است

امیرشاهرخی, کیوان ، خلیلی, علیرضا (1396) Methylsulfonylmethane در مقابل آسیب موکوس معده موثر است. European Journal of Pharmacology ــ 811 . ص.ص.240-248. شاپا 0014-2999

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آدرس اینترنتی رسمی : http://www.sciencedirect.com/science/article/pii/S...


عنوان انگليسی

Methylsulfonylmethane is effective against gastric mucosal injury

خلاصه انگلیسی

Methylsulfonylmethane (MSM) is a natural organosulfur compound has been widely used as a dietary supplement. MSM has protective effects against various disorders through its anti-inflammatory and antioxidant properties however the effect of MSM on gastric mucosal injury remains unclear. The aim of the present study is to determine whether MSM has beneficial effects on ethanol/HCl-induced gastric ulcer in mice. Macroscopic and histopathological evaluation of gastric mucosa revealed that ethanol/HCl administration produced apparent mucosal injuries, while pretreatment with MSM (200 and 400 mg/kg, orally) could effectively protect gastric mucosa against the injuries caused by acidified ethanol. MSM significantly increased the levels of glutathione (GSH), catalase (CAT) and prostaglandin E2 (PGE2), and decreased the levels of malondialdehyde (MDA), myeloperoxidase (MPO), carbonyl protein, and nitric oxide (NO) in gastric tissues compar ed with those in the ethanol group. MSM suppressed gastric inflammation by reducing the levels of proinflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, monocyte chemoattractant protein (MCP)-1 and matrix metalloproteinase (MMP)-9. Moreover, pretreatment of mice with MSM decreased the expression of nuclear factor kappa B (NF-κB) as a key regulator of inflammation in gastric mucosa. Taken together, these data suggest that MSM is able to decrease the severity of ethanol/HCl-induced gastric mucosal injury through inhibition of oxidative stress and inflammation.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده مسئول :کیوان امیرشاهرخی
نویسنده :علیرضا خلیلی
ضریب تاثیر و نمایه مجلات:IF(2016) 2.896 Indexed in: ISI, PubMed/Medline, Scopus
کلیدواژه ها (انگلیسی):Methylsulfonylmethane; Gastric ulcer; Oxidative stress; Inflammation; Ethanol
موضوعات :QV فارماکولوژی
بخش های دانشگاهی :دانشکده داروسازی > بخش فارماکولوژی
کد شناسایی :9131
ارائه شده توسط : دکتر کیوان امیرشاهرخی
ارائه شده در تاریخ :23 شهریور 1396 07:32
آخرین تغییر :10 مرداد 1401 12:44

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