title

اثر اسید لینولئیک کونژوگه بر استرس اکسیداتیو و متالوپروتئینازهای ماتریکس 2 و 9 در بیماران مبتلا به بیماری انسدادی مزمن ریوی

متین, سمیه and نعمتی, علی and قبادی مراللو, حسن and علی پناه مقدم, رضا and رضاقلی زاده, لطف اله (1397) اثر اسید لینولئیک کونژوگه بر استرس اکسیداتیو و متالوپروتئینازهای ماتریکس 2 و 9 در بیماران مبتلا به بیماری انسدادی مزمن ریوی. International Journal of Chronic Obstructive Pulmonary Disease ــ 13 . pp. 1449-1454. شاپا 1176-9106

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Title

The effect of conjugated linoleic acid on oxidative stress and matrix metalloproteinases 2 and 9 in patients with COPD

English Abstract

Background: Natural antioxidants in foods may be used in prevention and treatment of oxidative stress and inflammation in COPD. Therefore, this study aimed to evaluate the effect of conjugated linoleic acid (CLA) supplement as natural antioxidants on oxidative stress levels, and MMP2 and MMP9 serum levels in COPD patients. Materials and methods: This clinical trial study was conducted on 90 (supplement group=45 and control group=45) COPD patients in Ardabil city, Iran, in 2015. After obtaining written consent, general information was collected from each patient using a validated and reliable questionnaire. Supplement group received 3.2 g of CLA and those in the control group were given 3.2 g of placebo for 6 weeks on a daily basis. Fasting blood samples were taken from all of the patients for testing of malondialdehyde (MDA), MMP2, and MMP9 levels at the beginning and end of the study. Data were analyzed using Kolmogorov–Smirnov test, independent samples t-test, paired sample t-test, chi-square test, and ANOVA. Results: There were no significant differences between the two groups with regard to mean age, smoking status, and serum level of MDA at the beginning of the study. In the supplement group, the serum level of MDA decreased significantly at the end of the 6th week compared to that in the beginning of the study (p=0.0004), while in the placebo group, the difference was found to be insignificant. The serum level of MMP9 decreased significantly in the supplement group, while in the placebo group its level increased significantly as compared to that at the beginning of the study (p<0.05). The serum levels of MMP2 indicated no significant differences between the two groups neither at the beginning nor at the end of the study. Conclusion: These findings indicated that CLA supplementation may be helpful for COPD patients through inhibiting the production of oxidative stress and controlling MMP9 serum levels.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سمیه متین
نویسنده مسئول :علی نعمتی
نویسنده :حسن قبادی مراللو
نویسنده :رضا علی پناه مقدم
نویسنده :لطف اله رضاقلی زاده
Additional Information:Impact Factor (2016) 3.157 Indexed in: ISI, Pubmed/PMC/ Medline/Index Medicus, DOAJ, Google scholar
کلیدواژه ها (انگلیسی):COPD, CLA, oxidative stress, MMP2, MMP9
Subjects:QU Biochemistry
WF Respiratory System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:10023
Deposited By: دکتر لطف اله رضاقلی زاده
Deposited On:26 Feb 1397 09:13
Last Modified:01 Mar 1397 12:37

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