مطالعه سقط جنین مرتبط با Toxoplasma gondii در زنان به روش PCR جفت سقط شده و سرولوژی مادران در اردبیل

متین, سمیه and شهبازی, غلامرضا (1396) مطالعه سقط جنین مرتبط با Toxoplasma gondii در زنان به روش PCR جفت سقط شده و سرولوژی مادران در اردبیل. در: International Conference on Medical and Clinical Microbiology, July 03-04, 2017,, Bangkok, Thailand.


Official URL: https://www.omicsonline.org/proceedings


Study on abortion associated with Toxoplasma gondii in women based on PCR detection of aborted placenta and maternal serology in Ardabil, Iran

English Abstract

Infection with Toxoplasma Gondii in pregnant women may lead to abortion, stillbirth or other serious consequences in newborns. In the present study, the role of T. gondii in abortion in human was evaluated by molecular method and confirmatory serologic testing in Ardabil city, Iran. Two hundred samples of placenta and blood samples from women who had abortion in various gestational ages, admitted in Alavi Obstetric and Gynecological department of Ardabil were collected during 2013 to 2014. Blood samples were tested for specific anti-Toxoplasma antibodies by an enzyme linked immunosorbent assay (ELISA) and the placenta was tested by nested PCR, using 529 bp elements. Among all samples, maternal seroprevalence (anti-Toxoplasma IgM antibodies) was 5·8% to 14·2% (95% confidence interval) and the estimated abortion prevalence associated with T.gondii, based on PCR was calculated as being from 6.3% to 14.7% with 95% confidence interval. Results show moderate logical agreement between the 2 different tests (ĸ=0·44). A significant relationship was not observed between the presences of Toxoplasma with mother's age, history of abortion, gestational age and mother's disease such as allergy, diabetes, hypertension and hypothyroidism. The present findings reveals that T. gondii may be one of the potential agents in causing significant rate of abortion in the Ardabil area and placenta analysis is important to improve the sensitivity of the diagnosis .

Item Type:Conference or Workshop Item (Speech)
زبان سند : انگلیسی
نویسنده مسئول :سمیه متین
نویسنده :غلامرضا شهبازی
Subjects:QX Parasitology
WC Communicable Diseases
WP Gynecology
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:10039
Deposited By: دکتر سمیه متین
Deposited On:31 Apr 1398 12:25
Last Modified:06 May 1398 12:18

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