پتانسیل لیپوزوم های کاتیونی به عنوان سیستم های حویل/ادجوانتی برای واکسن های واکسن های زیرواحدی سل

خادمی, فرزاد and طاهری, رمضانعلی and ممتازی بروجنی, امیر عباس and فرنوش, غلامرضا and جانسون, توماس and صاحبکار, امیر حسین (1397) پتانسیل لیپوزوم های کاتیونی به عنوان سیستم های حویل/ادجوانتی برای واکسن های واکسن های زیرواحدی سل. Reviews of Physiology, Biochemistry and Pharmacology ــ online . شاپا 0303-4240

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Official URL: https://link.springer.com/chapter/10.1007/112_2018...


Potential of Cationic Liposomes as Adjuvants/Delivery Systems for Tuberculosis Subunit Vaccines

English Abstract

The weakness of the BCG vaccine and its highly variable protective efficacy in controlling tuberculosis (TB) in different age groups as well as in different geographic areas has led to intense efforts towards the development and design of novel vaccines. Currently, there are several strategies to develop novel TB vaccines. Each strategy has its advantages and disadvantages. However, the most important of these strategies is the development of subunit vaccines. In recent years, the use of cationic liposome-based vaccines has been considered due to their capacity to elicit strong humoral and cellular immune responses against TB infections. In this review, we aim to evaluate the potential for cationic liposomes to be used as adjuvants/delivery systems for eliciting immune responses against TB subunit vaccines. The present review shows that cationic liposomes have extensive applications either as adjuvants or delivery systems, to promote immune responses against Mycobacterium tuberculosis (Mtb) subunit vaccines. To overcome several limitations of these particles, they were used in combination with other immunostimulatory factors such as TDB, MPL, TDM, and Poly I:C. Cationic liposomes can provide long-term storage of subunit TB vaccines at the injection site, confer strong electrostatic interactions with APCs, potentiate both humoral and cellular (CD4 and CD8) immune responses, and induce a strong memory response by the immune system. Therefore, cationic liposomes can increase the potential of different TB subunit vaccines by serving as adjuvants/delivery systems. These properties suggest the use of cationic liposomes to produce an efficient vaccine against TB infections

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :فرزاد خادمی
نویسنده مسئول :رمضانعلی طاهری
نویسنده مسئول :امیر حسین صاحبکار
Additional Information:Impact Factor (2017) 3.235 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Embase
کلیدواژه ها (انگلیسی):Adjuvant, Cationic liposome, Delivery system ,M. tuberculosis, Subunit vaccine
Subjects:QV pharmacology > QV 704 Pharmaceutics
QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:10059
Deposited By: Dr Farzad Khademi
Deposited On:12 Apr 1397 15:18
Last Modified:12 Apr 1397 15:18

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