title

مصرف الکل و سرطان معده: متاآنالیز داده های منتشر شده در مقابل تجزیه و تحلیل داده های فردی (پروژه آنالیز تجمیعی سرطان معده)

Ferro, Ana and Morais, Samantha and Rota, Matteo and Pelucchi, Claudio and Bertuccio, Paola and Bonzi, Rossella and Galeone, Carlotta and Zhang, Zuo-Feng and Matsuo, Keitaro and Ito, Hidemi and Hu, Jinfu and Johnson, Kenneth C and Yu, Guo-Pei and Palli, Domenico and Ferraroni, Monica and Muscat, Joshua and ملک زاده, رضا and Ye, Weimin and Song, Huan and Zaridze, David and Maximovitch, Dmitry and Fernández de Larrea, Nerea and Kogevinas, Manolis and Vioque, Jesus and Navarrete-Muñoz, Eva M and پاک سرشت, محمدرضا and پورفرضی, فرهاد and Wolk, Alicja and Orsini, Nicola and Bellavia, Andrea and Håkansson, Niclas and Mu, Lina and Pastorino, Roberta and Kurtz, Robert C and درخشان, محمدحسین and Lagiou, Areti and Lagiou, Pagona and Boffetta, Paolo and Boccia, Stefania and Nagri, Eva and La Vecchia, Carlo and Peleteiro, Bárbara and Lunet, Nuno (1397) مصرف الکل و سرطان معده: متاآنالیز داده های منتشر شده در مقابل تجزیه و تحلیل داده های فردی (پروژه آنالیز تجمیعی سرطان معده). Cancer Epidemiology ــ 54 (2018). pp. 125-132. شاپا 1877-7821

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Title

Alcohol intake and gastric cancer: Meta-analyses of published data versus individual participant data pooled analyses (StoP Project)

English Abstract

Background Individual participant data pooled analyses allow access to non-published data and statistical reanalyses based on more homogeneous criteria than meta-analyses based on systematic reviews. We quantified the impact of publication-related biases and heterogeneity in data analysis and presentation in summary estimates of the association between alcohol drinking and gastric cancer. Methods We compared estimates obtained from conventional meta-analyses, using only data available in published reports from studies that take part in the Stomach Cancer Pooling (StoP) Project, with individual participant data pooled analyses including the same studies. Results A total of 22 studies from the StoP Project assessed the relation between alcohol intake and gastric cancer, 19 had specific data for levels of consumption and 18 according to cancer location; published reports addressing these associations were available from 18, 5 and 5 studies, respectively. The summary odds ratios [OR, (95%CI)] estimate obtained with published data for drinkers vs. non-drinkers was 10% higher than the one obtained with individual StoP data [18 vs. 22 studies: 1.21 (1.07–1.36) vs. 1.10 (0.99–1.23)] and more heterogeneous (I 2 : 63.6% vs 54.4%). In general, published data yielded less precise summary estimates (standard errors up to 2.6 times higher). Funnel plot analysis suggested publication bias. Conclusion Meta-analyses of the association between alcohol drinking and gastric cancer tended to overestimate the magnitude of the effects, possibly due to publication bias. Additionally, individual participant data pooled analyses yielded more precise estimates for different levels of exposure or cancer subtypes.

Item Type:Article
زبان سند : انگلیسی
نویسنده :رضا ملک زاده
نویسنده :محمدرضا پاک سرشت
نویسنده :فرهاد پورفرضی
نویسنده :محمدحسین درخشان
Additional Information:IF(2016) 2.343 Indexed in: ISISciSearch/Science Citation Index Expanded , Journal Citation Reports - Science Edition, Pubmed/Medline, Scopus, Current Contents / Clinical Medicine,
کلیدواژه ها (انگلیسی):Alcohol; Gastric cancer; Individual participant data; Meta-analysis; Pooled analysis; Publication bias
Subjects:QZ Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
ID Code:10094
Deposited By: MS Soghra Golmaghani
Deposited On:12 Mar 1397 09:41
Last Modified:12 Mar 1397 10:37

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