title

تومور تروببلاستی و کریوکارسینوما از سزارین قبلی بخش اسکار: گزارش مورد

نصیری, ستاره and شیخ حسنی, شهرزاد and موسوی, اعظم سادات and مدرس گیلانی, میترا and اخوان, ستاره and وکیلی, محمدرحیم (1397) تومور تروببلاستی و کریوکارسینوما از سزارین قبلی بخش اسکار: گزارش مورد. Iranian Journal of Medical Sciences ــ online . pp. 1-6. شاپا 0253-0716

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Official URL: http://ijms.sums.ac.ir/index.php/IJMS/article/view...


Title

Placenta Site Trophoblastic Tumor and Choriocarcinoma from Previous Cesarean Section Scar: Case Reports

English Abstract

Choriocarcinoma and placental site trophoblastic tumor (PSTT) are rare varieties of gestational trophoblastic disease (GTD). PSTT alone constitutes about 1-2% of all trophoblastic tumors, which presents at early reproductive age and the serum beta-hCG level is much lower than choriocarcinoma. This tumor usually invades the myometrium and its depth of penetration is a prognostic factor. The first case report is regarding a 33-year-old woman with vaginal bleeding 3 months after abortion. The ultrasound exhibited heterogeneous and hypervascular mass related to previous cesarean scar. Serum beta-hCG level was 67 mIU/ml and chemotherapy was administered. However, due to severe vaginal bleeding and no regression in mass size, total abdominal hysterectomy was performed. Histopathological examination and IHC staining confirmed PSTT from previous cesarean section. The second case report is regarding a 33-year-old woman with cervicoisthmic choriocarcinoma, which was mistaken as cesarean scar pregnancy. The ultrasonography and elevated serum beta-hCG level suggested cesarean scar pregnancy. The patient was treated with methotrexate without any effect. Eventually, cervicoisthmic choriocarcinoma was detected after hysterectomy. A diagnostic error was made leading to possible uterus perforation along with incorrect chemotherapy that resulted in a life-threatening condition. It is concluded that PSTT and choriocarcinoma are the two important differential diagnoses of sustained elevated beta-hCG when imaging evidence is also suggestive. Although PSTT and cervicoisthmic choriocarcinoma are rare, they do exist and are on the rise.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :ستاره نصیری
نویسنده :محمدرحیم وکیلی
Additional Information:Indexed in: ESCI, Pubmed/PMC, Scopus, Chemical Abstracts,CINAHL, DOAJ, Index Medicus for the WHO Eastern Mediterranean Region, Index Copernicus, ISC, Google Scholar, SID, Magiran, Barakatkns, MedLib, RICeST
کلیدواژه ها (انگلیسی):Trophoblastic neoplasms; Cesarean scar; pregnancy; Trophoblastic tumor; Placental site
Subjects:WO Surgery
WQ Obstetrics
Divisions:Faculty of Medicine > Department of Surgery
ID Code:10138
Deposited By: Ms Zeynab Imani
Deposited On:30 Mar 1397 11:46
Last Modified:30 Mar 1397 11:47

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