پیش آگهی اولیه و میان مدت درمان ترومبولیتیک داخل وریدی در انواع سکته مغزی ایسکمیک حاد

پاشاپور, علی and عطالو, ابوالفضل and فرهودی, مهدی and طاهراقدم, علی اکبر and صادقی حکم ابادی, الیار and شریفی پور, احسان and نجفی, مهدی (1392) پیش آگهی اولیه و میان مدت درمان ترومبولیتیک داخل وریدی در انواع سکته مغزی ایسکمیک حاد. Pakistan Journal of Medical Sciences ــ 29 (1). pp. 181-186. شاپا 1682-024X


Official URL: https://www.pjms.com.pk/index.php/pjms/article/vie...


Early and intermediate prognosis of intravenous thrombolytic therapy in acute ischemic stroke subtypes according to the causative classification of stroke system.

English Abstract

OBJECTIVES: Intravenous thrombolytic therapy has established acceptable results in treating ischemic stroke. However, there is little information on treatment outcome especially in different subtypes. The aim of current study was to evaluate early and intermediate prognosis in intravenous thrombolytic therapy for acute ischemic stroke subtypes. METHODOLOGY: Forty eligible patients (57.5% male with mean age of 63.18±13.49 years) with definite ischemic stroke who were admitted to emergency department of Imam Reza University Hospital, in the first 180 minutes after occurrence received recombinant tissue plasminogen activator. All investigation findings were recorded and stroke subtypes were determined according to the Causative Classification of Stroke System. Stroke severity forms including modified Rankin Scale (mRS) and National Institutes of Health Stroke Scale (NIHSS) scores were recorded for all patients in first, seven and 90 days after stroke and disease outcome was evaluated. RESULTS: The etiology of stroke was large artery atherosclerosis in 20%, cardio-aortic embolism in 45%, small artery occlusion in 17.5% and undetermined causes in 17.5%. NIHSS and mRS scores were significantly improved during time (P < 0.001 in both cases). Three months mortality rate was 25%. Among the etiologies, patients with small artery occlusion and then cardio-aortic embolism had lower NIHSS score at arrival (P = 0.04). Caplan-meier analysis showed that age, sex and symptom to needle time could predict disease outcome. CONCLUSION: Intravenous thrombolytic therapy is accompanied by good early and intermediate outcome in most patients with ischemic stroke. Small artery occlusion subtype had less disease severity and higher improvement.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :علی پاشاپور
نویسنده مسئول :ابوالفضل عطالو
Additional Information:Impact Factor(2013) 0.098 Indexed in: ISI, Pubmed/PMC, Scopus, Embase/Excerpta Medica Netherlands, WHO IMEMR Current Contents
کلیدواژه ها (انگلیسی):Ischemic stroke, Thrombolytic therapy, Etiology, Outcome, Ischemic Stroke Subtypes
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Surgery
ID Code:10177
Deposited By: Dr Firouz Amani
Deposited On:05 Apr 1397 11:33
Last Modified:05 Apr 1397 11:33

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