در تجزیه و تحلیل Vivo از آپوپتوز در هیپوکامپ جنین

سلیمی, احمد and پوراحمد, جلال (1397) در تجزیه و تحلیل Vivo از آپوپتوز در هیپوکامپ جنین. در: Teratogenicity Testing: Methods and Protocols. Humana Press, New York, pp. 531-536. شابک 978-1-4939-7882-3



In Vivo Analysis of Apoptosis in Embryonic Hippocampus

English Abstract

Apoptosis is fundamental in several morphogenetic processes and ultimately determines the mass, shape, and function of the various tissues and organs that form the animal body. This process is a gene-regulated process that plays fundamental roles in several normal and pathological conditions. Apoptosis is most often detected during embryonic development. Although the nervous tissue is traditionally regarded as being fundamentally constituted by postmitotic nonproliferating cells, analysis of cell proliferation and apoptosis in vivo has recently gained an increasing importance mainly during embryonic development because there is large evidence that drug-induced apoptosis is the most likely candidate for the behavioral deficits. These effects occur at therapeutically relevant blood levels, and require only a relatively brief exposure. We describe here a of techniques that are currently for the detection of apoptotic cells in the central nervous system (CNS) directly on tissue sections in postnatal mice.

Item Type:Book Section
زبان سند : انگلیسی
نویسنده اول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Uncontrolled Keywords:آپوپتوز، هیپوکامپ، دارو، موش، جنین
کلیدواژه ها (انگلیسی):Apoptosis, Hippocampus, Drug, Mouse, Embryos
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
School of Pharmacy > Department of Pharmacology
ID Code:10184
Deposited By: دکتر احمد سلیمی
Deposited On:22 Jul 1397 10:53
Last Modified:22 Jul 1397 10:53

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