اثرات ضد ویروسینانومیسل های کورکومین بر روی اتصال و ورود ویروس هپاتیت سی

ناصری, سجاد and درودی, مجید and آریان, احسان and قلوبی, آیدا and رحیمی, حمیدرضا and کتابی, کیانا and موقر, عارف and عبدلی, اصغر and گوکلانی, حامد and تیمورپور, رقیه and مشکات, زهرا (1396) اثرات ضد ویروسینانومیسل های کورکومین بر روی اتصال و ورود ویروس هپاتیت سی. Iranian Journal of Virology ــ 11 (2). pp. 29-35. شاپا 1735-5680


Official URL: http://journal.isv.org.ir/article-1-319-en.html


The Antiviral Effects of Curcumin Nanomicelles on the Attachment and Entry of Hepatitis C Virus

English Abstract

Background and Aims: Hepatitis C virus (HCV) is a member of the Flaviviridae family, which causes approximately 500,000 deaths annually. HCV infection treatment is often associated with significant adverse effects. Curcumin is an active ingredient of turmeric which has therapeutic anti-inflammatory effects in many diseases including infectious ones. Although curcumin is not soluble in water, if it is synthesized in the form of nanomicelles, it will be water soluble and can be absorbed in the gastrointestinal tract (GI). In this study, the antiviral effects of curcumin nanomicelles were investigated on the attachment and entry of HCV particles. Materials and Methods: The cytotoxicity of curcumin nanomicelles was determined in Huh7.5 cells and their antiviral effects on the attachment and entry of HCV was investigated in a cell culture system. Results: Curcumin nanomicelles could decrease the viral load in the cell culture supernatants compared to virus control. Conclusions: According to the results of this research, we determined the antiviral effects of curcumin nanomicelles in the later stages of HCV replication.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سجاد ناصری
نویسنده :رقیه تیمورپور
نویسنده مسئول :زهرا مشکات
Additional Information:Indexed in: SID, ISC, Google Scholar
کلیدواژه ها (انگلیسی):Hepatitis C virus, Curcumin, Herbal medicines, Nanomicelles
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Microbiology
ID Code:10229
Deposited By: Dr Roghayeh Teimourpour
Deposited On:17 Apr 1397 12:25
Last Modified:17 Apr 1397 12:25

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