مقایسه لووتیراستام و سدیم والپرات در پیشگیری از میگرن: یک کارازمایی بالینی تصادفی شده

عباسی, وحید and عطالو, ابوالفضل and صدیق نیا, پرهام (1397) مقایسه لووتیراستام و سدیم والپرات در پیشگیری از میگرن: یک کارازمایی بالینی تصادفی شده. International Journal of Basic & Clinical Pharmacology ــ 7 (8). pp. 1460-1463. شاپا 2003-2319


Official URL: http://www.ijbcp.com/index.php/ijbcp/article/view/...


Comparison of Levetiracetam and sodium Valproate in the prevention of migraine: a randomized clinical trial study

English Abstract

Background: Sodium valproate is an anti-seizure drug used for prophylactic use of migraine headaches. Despite the efficacy of this drug due to complications that cause some patients to not tolerate the drug. The purpose of this study was to Comparison of levotiracetam and Sodium valproate in migraine prophylaxis. Methods: This is a clinical trials study. 100 migraineurs who referred to the Alavi neurology clinic and indicated the onset of prophylaxis of migraine were studied in two groups of 50, one of which was a group of levetiracetam and another group of sodium valproate Received. Patients received daily 500mg of drug for 3 months and the effect of the drug on the number of attacks, severity of attacks, and MIDAS score was measured. Collected data analyzed by statistical methods in SPSS version 19. P<0.05 was considered as significant. Results: In both cases, significant improvement was observed in the number of attacks, severity and MIDAS score. In all of the criteria, levetiracetam and sodium valproate were almost identical, except for reducing the number of headache attacks that had a significantly in levothyramine group less than sodium valporoste group (P = 0.0001). Conclusions: This study showed that levothyramineacetamin can be used as a good alternative in those who do not tolerate sodium valproate.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :وحید عباسی
نویسنده مسئول :ابوالفضل عطالو
Additional Information:Indexed in: Index Copernicus
کلیدواژه ها (انگلیسی):Levetiracetam, Migraine, Sodium valproate
Subjects:WL Nervous system
Divisions:Faculty of Medicine > Department of Surgery
ID Code:10293
Deposited By: Dr Firouz Amani
Deposited On:06 May 1397 10:55
Last Modified:31 Jan 1400 10:40

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