تهیه، بهینه سازی و ارزیابی آزمایشگاهی سیستم آهسته رهش پرامی پکسول با استفاده از نانوذرات پلی هیدروکسی بوتیرات والرات

بهاری جوان, نیکا and جعفری امید, نرسی and موسوی حصب, نگار and رضایی شیرمرد, لیلا and رفیعی تهرانی, مرتضی and درکوش, فرید (1397) تهیه، بهینه سازی و ارزیابی آزمایشگاهی سیستم آهسته رهش پرامی پکسول با استفاده از نانوذرات پلی هیدروکسی بوتیرات والرات. Journal of Drug Delivery Science and Technology ــ 44 . pp. 82-90. شاپا 1773-2247

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Preparation, statistical optimization and in vitro evaluation of pramipexole prolonged delivery system based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) nanoparticles

English Abstract

The purpose of the current study was to prepare and optimize a long acting formulation for pramipexole based on poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) nanoparticles (NPs). Pramipexole loaded PHBV NPs were prepared by double emulsion solvent evaporation technique. Box-behnken response surface methodology was utilized to assess the effect of independent variables including PVA concentration, polymer percentage and drug concentration on important properties of NPs. The optimized NPs was shown 228 nm size with 85.43% and 5.68% entrapment efficiency and loading capacity, respectively. The spherical structure of the pramipexole loaded PHBV NPs was proved by scanning electron microscope (SEM). Differential scanning calorimetry (DSC) testified both the absence of undesirable chemical interactions between pramipexole and NPs and the incorporation of pramipexole within the matrix of polymer. In vitro release studies demonstrated that 89.9% of pramipexole was gradually released within 30 days based on quasi-fickian diffusion mechanism.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :نیکا بهاری جوان
نویسنده :نرسی جعفری امید
نویسنده :نگار موسوی حصب
نویسنده :لیلا رضایی شیرمرد
نویسنده :مرتضی رفیعی تهرانی
نویسنده مسئول :فرید درکوش
Additional Information:Impact Factor (2017) 2.297 Indexed in: ISI, Scopus, Embase
کلیدواژه ها (انگلیسی):Pramipexole, poly (3-hydroxybutyrate-co-3-hydroxyvalerateacid), Nanoparticles, prolonged delivery
Subjects:QV pharmacology > QV 704 Pharmaceutics
Divisions:School of Pharmacy > Department of Pharmaceutics
ID Code:10331
Deposited By: Dr Leila Rezaie Shirmard
Deposited On:07 May 1397 15:27
Last Modified:08 May 1397 09:28

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