تب مديترانه اي فاميليال در شمال غربي ايران ،اولين گزارش جامع

صالح زاده, فرهاد and امامی, دینا and ذولفقاری, علی اصغر and یزدانبد, عباس and حبیب زاده, شهرام and بشردوست, بهمن and براک, منوچهر and فیضی, ایرج and عظیمی, هرمز and جستان, مارینا and خلفی, جعفر (1387) تب مديترانه اي فاميليال در شمال غربي ايران ،اولين گزارش جامع. Turkish Journal of Pediatrics ــ 50 (1). pp. 40-44. شاپا 0041-4301

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Familial Mediterranean fever in northwest of Iran (Ardabil): The first global report from Iran

English Abstract

Familial Mediterranean fever (FMF), which is the prototype of the hereditary periodic fever syndromes, is common in the countries around the Mediterranean Sea. Considering its geographical position in the northwest of Iran, with its population of Turkish origin and its vicinity to the Mediterranean Sea, the incidence of FMF should be high in Ardabil. The goal of this study was to introduce FMF as a disease with significant outbreak in this area. Based on the Tel-Hashomer criteria, patients suffering from FMF were collected from private clinics together with the medical records of adult and pediatric rheumatology clinics. Of 112 total patients determined, 74 were studied. All of the patients were interviewed and completed a questionnaire. Familial Mediterranean fever was common among children under 18 years (76%), and it was more common in males than females (M/F 1.17). Abdominal pain was the most common complaint (74%) and abdominal pain and fever (95% and 84%, respectively) were the main clinical symptoms. The average duration of pain was 12-72 hours and the average recovery (attack-free period) was from one week to one month (63.5%). The majority of the patients had hospital admission for diagnostic work-up (85%) and some (32%) had undergone surgical operation erroneously; 92% of the patients had taken medications with incorrect diagnosis; and 20% had positive familial history of FMF. Fifty percent of the patients' parents were first-degree relatives and in 59.5% delay in diagnosis was more than three years. It seems that FMF is more common in the Northwest of Iran than previously thought, although physicians are not familiar with it. The common age for manifestation of this disease is under 18 years and its presentation after the age of 40 years is very rare.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :فرهاد صالح زاده
Additional Information:cited By (since 1996) 0 Impact Factor:0.442 Indexed in ISI , Medline/Pubmed 2-BIOSIS Previews,EMBASE/Excerpta Medica, EBSCOhost (Medline with Full Text), 3-CABI Abstracts (Helminthological Abstracts, Nutrition Abstracts and Reviews Series A, Protozoological Abstracts, Review of Medical and Veterinary Entomology), IBIDS (International Bibliographic Information on Dietary Supplements), ProQuest (Medline, Professional ProQuest Central,ProQuest Central, ProQuest Health and Medical Complete, ProQuest Medical Library, ProQuest Pharma Collection) and Science Citation Index (SCI) Expanded.
کلیدواژه ها (انگلیسی):antibiotic agent; antipyretic agent; colchicine; nonsteroid antiinflammatory agent, abdominal pain; adolescent; adult; article; child; clinical feature; delayed diagnosis; diagnostic error; diarrhea; familial Mediterranean fever; family history; female; fever; geographic distribution; hospital admission; human; incidence; interview; Iran; major clinical study; male; medical record review; onset age; questionnaire; sex ratio; surgical error, Adolescent; Adult; Child; Child, Preschool; Colchicine; Consanguinity; Familial Mediterranean Fever; Female; Gout Suppressants; Humans; Infant; Iran; Male; Middle Aged; Pain Measurement; Questionnaires
Subjects:WE Musculoskeletal system
WB Practice of Medicine
Divisions:Faculty of Medicine > Department of Pediatrics , Community Medicine
Faculty of Medicine > Department of Surgery
Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:1035
Deposited By: Dr Shahram Habibzadeh
Deposited On:09 Dec 1388 06:03
Last Modified:10 Jul 1393 06:52

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