title

دوز Eptifibatide بولوس در طی انتخابی Percutaneous مداخلات کرونری

دوستکامی, حسین ، صادقیه اهری, سعید ، ایرانی جم, عفت ، حبیب زاده, افشین (1397) دوز Eptifibatide بولوس در طی انتخابی Percutaneous مداخلات کرونری. Cardiology Research ــ 9 (2). ص.ص.107-110. شاپا 1923-2829

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عنوان انگليسی

Eptifibatide Bolus Dose During Elective Percutaneous Coronary Intervention

خلاصه انگلیسی

Background: Eptifibatide is a platelet glycoprotein IIb/IIIa receptor antagonist used for the prevention of cardiac ischemic complications of percutaneous coronary intervention (PCI). Eptifibatide has been used with bolus dose only or bolus plus infusion in patients undergoing PCI which have shown less complications, but the risk of bleeding has been increased. We aimed to compare the outcome and bleeding rate of bolus dose alone or plus infusion in elective PCI. Methods: In this quasi-experimental study, we compared the outcome of elective PCI following single bolus dose intracoronary (41 patients) or bolus plus intravenous infusion (19 patients) of eptifibatide. In-hospital and follow-up major adverse cardiac events (MACEs) and bleeding rate were recorded and evaluated between groups. Results: Both groups were comparable regarding baseline findings. Bolus only compared to bolus plus infusion group had lower in-hospital (19.5% vs. 31.6%) and follow-up MACE (15.4% vs. 17.6%), lower bleeding in-hospital (14.6% vs. 21.1%) and follow-up (2.4% vs. 5.3%) as well as lower mortality rate in hospital (4.9% vs. 15.8%), but higher follow-up mortality (10.3% vs. 0), but the difference was not significant. Conclusions: We observed no significant difference regarding bleeding or MACE between intracoronary bolus infusion and bolus plus intravenous infusion of eptifibatide. It seems intracoronary bolus infusion of eptifibatide due to use of lower doses is a better choice in elective PCI to prevent post-PCI MACE.

نوع سند :مقاله
زبان سند : انگلیسی
نویسنده اول :حسین دوستکامی
نویسنده :سعید صادقیه اهری
نویسنده مسئول :عفت ایرانی جم
نویسنده :افشین حبیب زاده
ضریب تاثیر و نمایه مجلات:Indexed in: ESCI, Pubmed/PMC, EBSCOhost, EMBASE, Worldcat, Google Scholar
کلیدواژه ها (انگلیسی):Eptifibatide; Bolus dose; Percutaneous coronary intervention
موضوعات :WG سیستم قلب و عروق
بخش های دانشگاهی :دانشكده پزشكي > گروه اطفال ، پزشکی اجتماعی
دانشكده پزشكي > گروه داخلی ، قلب ، عفونی
کد شناسایی :10393
ارائه شده توسط : دکتر حسین دوست کامی
ارائه شده در تاریخ :20 مرداد 1397 12:42
آخرین تغییر :20 مرداد 1397 12:42

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