title

اثرات ویتامین D و امگا 3 چربی اسیدهای کادمیوم در بیومارکرهای التهاب، استرس اکسیداتیو و نتایج حاملگی در بیماران با دیابت بارداری

رضوی, مریم السادات and جمیلیان, مهری and صمیمی, منصوره and افشار ابراهیمی, فرانه and تقی زاده, محسن and بخردی, رضا and سید حسیمی, الهه and حداد کاشانی, حامد and کرمعلی, مریم and عاصمی, ذات اله (1396) اثرات ویتامین D و امگا 3 چربی اسیدهای کادمیوم در بیومارکرهای التهاب، استرس اکسیداتیو و نتایج حاملگی در بیماران با دیابت بارداری. Nutrition & Metabolism ــ 14 . pp. 1-9. شاپا 1743-7075

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Title

The effects of vitamin D and omega-3 fatty acids co-supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in patients with gestational diabetes

English Abstract

Background This study was carried out to determine the effects of vitamin D and omega-3 fatty acids co- supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes (GDM) patients. Methods This randomized, double-blind, placebo-controlled trial was conducted among 120 GDM women. Participants were randomly divided into four groups to receive: 1) 1000 mg omega-3 fatty acids containing 180 mg eicosapentaenoic acid (EPA) and 120 mg docosahexaenoic acid (DHA) twice a day + vitamin D placebo (n = 30); 2) 50,000 IU vitamin D every 2 weeks + omega-3 fatty acids placebo (n = 30); 3) 50,000 IU vitamin D every 2 weeks + 1000 mg omega-3 fatty acids twice a day (n = 30) and 4) vitamin D placebo + omega-3 fatty acids placebo (n = 30) for 6 weeks. Results Subjects who received vitamin D plus omega-3 fatty acids supplements compared with vitamin D, omega-3 fatty acids and placebo had significantly decreased high-sensitivity C-reactive protein (−2.0 ± 3.3 vs. -0.8 ± 4.4, −1.3 ± 2.4 and +0.9 ± 2.7 mg/L, respectively, P = 0.008), malondialdehyde (−0.5 ± 0.5 vs. −0.2 ± 0.5, −0.3 ± 0.9 and +0.5 ± 1.4 μmol/L, respectively, P < 0.001), and increased total antioxidant capacity (+92.1 ± 70.1 vs. +55.1 ± 123.6, +88.4 ± 95.2 and +1.0 ± 90.8 mmol/L, respectively, P = 0.001) and glutathione (+95.7 ± 86.7 vs. +23.0 ± 62.3, +30.0 ± 66.5 and −7.8 ± 126.5 μmol/L, respectively, P = 0.001). In addition, vitamin D and omega-3 fatty acids co-supplementation, compared with vitamin D, omega-3 fatty acids and placebo, resulted in lower incidences of newborns’ hyperbilirubinemiain (P = 0.037) and newborns’ hospitalization (P = 0.037). Conclusion Overall, vitamin D and omega-3 fatty acids co-supplementation for 6 weeks among GDM women had beneficial effects on some biomarkers of inflammation, oxidative stress and pregnancy outcomes.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مریم السادات رضوی
نویسنده مسئول :مهری جمیلیان
Additional Information:Impact Factor (2017) 3.483 Indexed in: ISI, Pubmed/PMC, Scopus, Chemical Abstracts, DOAJ, Embase, Cinahl, CABI
کلیدواژه ها (انگلیسی):Vitamin D, Omega-3 fatty acids, Supplementation, Gestational diabetes, Pregnancy outcomes
Subjects:WP Gynecology
Divisions:Faculty of Medicine > Department of Anesthesiology , Obstetrics & Gynecology
ID Code:10434
Deposited By: Ms Zeynab Imani
Deposited On:01 Jun 1397 12:11
Last Modified:18 Jun 1397 13:09

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