title

بررسی اثر N-استیل سیستین خوراکی بر روی سطح کمی High sensitivity CRP سرمی و هموگلوبین در بیماران مبتلا به نارسایی مزمن کلیوی تحت همودیالیز-یک مطالعه کارآزمایی بالینی

بشردوست, بهمن and علایی, رویا and محمدی کبار, سوسن and حسنی, صباح and حبیب زاده, افشین (1397) بررسی اثر N-استیل سیستین خوراکی بر روی سطح کمی High sensitivity CRP سرمی و هموگلوبین در بیماران مبتلا به نارسایی مزمن کلیوی تحت همودیالیز-یک مطالعه کارآزمایی بالینی. Journal of Nephropathology ــ 7 (4). pp. 268-272. شاپا 2251-8363

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Official URL: http://www.nephropathol.com/Abstract/jnp-201808251...


Title

The effect of oral N-acetylcysteine on serum high sensitive CRP and plasma hemoglobin levels in end-stage renal disease patients under routine hemodialysis; a randomized placebocontrolled clinical trial

English Abstract

Background: Oxidative stress and systemic inflammation is increased in end-stage renal disease (ESRD) patients. Due to the various effects of oxidative stress in ESRD patients, different antioxidants have been evaluated. Objectives: In this study, we evaluated the effect of oral N-acetylcysteine (NAC) as an antioxidant on the serum high-sensitive C-reactive protein (hs-CRP) and plasma hemoglobin levels in the ESRD patients who were under routine hemodialysis. Patients and Methods: In this randomized placebo-controlled clinical trial, 51 ESRD patients under routine hemodialysis were randomly assigned to receive NAC 1200 mg daily for 1 month (n=26) or placebo (n=25). Laboratory findings including hemoglobin, ferritin, hsCRP were measured in patients before and after treatment. Results: NAC group compared to placebo group had significantly higher ferritin levels before treatment (p=0.02) and lower phosphorus levels after treatment (p=0.03). Comparing the results before and after treatment in each group, a significant reduction in hematocrit (p=0.002), ferritin (p=0.006), hs-CRP (p=0.02) and an increase in alkaline phosphatase levels (p=0.005) in NAC group and significant reduction in calcium levels (p<0.001) in placebo group was detected. No major side effects were seen. Conclusions: One month treatment with oral NAC resulted in reduced levels of hematocrit, ferritin and Hs-CRP, indicative of role of NAC in controlling inflammation in ESRD patients under hemodialysis. However, NAC was not effective in treatment of anemia, although the treatment duration was low.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :بهمن بشردوست
نویسنده مسئول :رویا علایی
نویسنده :سوسن محمدی کبار
Additional Information:Indexed in: SCopus, DOAJ, Google Scholar, Index Copernicus
کلیدواژه ها (انگلیسی):End-stage renal disease, high sensitivity CRP, N-acetylcysteine, Hemoglobin
Subjects:WJ Urogenital System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:10485
Deposited By: دکتر سمیه متین
Deposited On:12 Jun 1397 14:17
Last Modified:12 Jun 1397 14:17

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