ارتباط بین ترکیبات ارگانوفسفره و بیماریهای نورودژنراتیو بر اساس شواهد و مکانیسم ها

مصطفی لو, سارا and عبدالهی, محمد (1397) ارتباط بین ترکیبات ارگانوفسفره و بیماریهای نورودژنراتیو بر اساس شواهد و مکانیسم ها. Toxicology ــ 409 . pp. 44-52. شاپا 0300-483X

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The link of organophosphorus pesticides with neurodegenerative and neurodevelopmental diseases based on vidence and mechanisms

English Abstract

Organophosphorus (OP) compounds have been known as the most widely used pesticides during the past half century and there have been a huge body of literature regarding their association with human chronic diseases. Neurodegenerative and neurodevelopmental disorders including Alzheimer, Parkinson, amyotrophic lateral sclerosis (ALS), attention deficit hyperactivity disorder (ADHD), and autism are among the afflicting neurological diseases which overshadow human life and their higher risk in relation to OP exposures have been uncovered by epidemiological studies. In addition, experimental studies exploring the underlying mechanisms have provided some evidence for involvement of cholinergic deficit, oxidative stress, neuro-inflammation, and epigenetic modifications as the processes which are common in the toxicity of the OP and pathophysiology of the mentioned diseases. In addition, genetic mutations and polymorphisms of different variants of some genes like paraoxonase have been shown to be implicated in both susceptibility to OPs toxicity and neurological diseases. In this article, we reviewed the epidemiological as well as experimental studies evidencing the association of exposure to OPs and incidence of neurodegenerative and neurodevelopmental diseases.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سارا مصطفی لو
نویسنده مسئول :محمد عبدالهی
Additional Information:Impact Factor (2017) 3.265 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, EMBASE, EMBiology, BIOSIS, Current Contents/Life Sciences,
کلیدواژه ها (انگلیسی):Environmental toxicology; Neurodegenerative diseases; Neurodevelopmental disorders; Organophosphorus; Pesticide
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:10492
Deposited By: Dr Sara Mostafalou
Deposited On:13 Jun 1397 14:26
Last Modified:13 Jun 1397 14:26

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