مطالعه بر روی فیبرینوژنزیس آلفا کموتریپسین القا شده توسط کوسالونتها: آیا هیدروفوبیسیته سطحی میتواند واکنش توده ای شدن را آغاز نماید؟

خدارحمی, رضا and سوری, حسنیه and امانی, مجتبی (1388) مطالعه بر روی فیبرینوژنزیس آلفا کموتریپسین القا شده توسط کوسالونتها: آیا هیدروفوبیسیته سطحی میتواند واکنش توده ای شدن را آغاز نماید؟. The Protein Journal ــ 28 (7-8). pp. 349-361. شاپا 1572-3887

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Study of cosolvent-induced α-chymotrypsin fibrillogenesis: Does protein surface hydrophobicity trigger early stages of aggregation reaction?

English Abstract

The misfolding of specific proteins is often associated with their assembly into fibrillar aggregates, commonly termed amyloid fibrils. Despite the many efforts expended to characterize amyloid formation in vitro, there is no deep knowledge about the environment (in which aggregation occurs) as well as mechanism of this type of protein aggregation. Alpha-chymotrypsin was recently driven toward amyloid aggregation by the addition of intermediate concentrations of trifluoroethanol. In the present study, approaches such as turbidimetric, thermodynamic, intrinsic fluorescence and quenching studies as well as chemical modification have been successfully used to elucidate the underlying role of hydrophobic interactions (involved in early stages of amyloid formation) in α-chymotrypsin-based experimental system. © 2009 Springer Science+Business Media, LLC.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :رضا خدارحمی
نویسنده :مجتبی امانی
Additional Information:cited By (since 1996) 1 Impact Factor: 0.94 Abstracted/Indexed in:1-ISI 2-SCOPUS,BIOSIS ,Chemical Abstracts Service (CAS)-Current Contents/ Life Sciences,EMBASE,PubMed/Medline, 3-Academic OneFile, Academic Search, ASFA, Biochemistry and Biophysics Citation Index, Biological Abstracts, Previews, CAB Abstracts, CAB International, ChemWeb, CSA/Proquest, Current Abstracts, Current Awareness in Biological Sciences (CABS), Elsevier Biobase, EMBiology, Gale, Global Health, Google Scholar, IBIDS, Journal Citation Reports/Science Edition, OCLC, Summon by Serial Solutions, TOC Premier, VINITI - Russian Academy of Science
کلیدواژه ها (انگلیسی):amyloid; chymotrypsin A, article; chemical modification; experimental study; fluorescence; hydrophobicity; protein aggregation; thermodynamics; turbidimetry
Subjects:QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:1057
Deposited By: MS Soghra Golmaghani
Deposited On:13 Dec 1388 04:50
Last Modified:20 Jan 1393 12:49

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