سطوح افزایش یافته mRNA و DNA ژن hTERT در بیماران مبتلا به سرطان معده در شمال غرب ایران

حسینی اصل, سید سعید and اخوان, هما (1397) سطوح افزایش یافته mRNA و DNA ژن hTERT در بیماران مبتلا به سرطان معده در شمال غرب ایران. در: Molecular Analysis for Personalised Therapy (MAP), Sep 14-15 , 2018, Paris - France.


Official URL: https://academic.oup.com/annonc/article/29/suppl_6...


Elevated plasma levels of hTERT mRNA and DNA in patients with gastric cancer in Northwest of Iran

English Abstract

Background: Gastric cancer (GC) as the fourth common cancer over the world and responsible for the second cause of cancer-related deaths, has high incidence rate in Iran and especially in its North-Western province, Ardabil. In this study, the circulating hTERT mRNA and DNA were studied in patients affected with GC in Ardabil. Methods: Using conventional PCR and RT-PCR, Q-PCR and Q-RT-PCR, evaluating the circulating hTERT nucleic acids in the plasma samples of the 100 GC cases and the same number of sex-, age-, and residence place adjusted healthy volunteers, as the control group has been done. Results: The circulating hTERT mRNA level in patients was higher (40X) than the controls. In the case of circulating DNA, cases had higher difference (65X). These findings have been evaluated as significant difference. There were no significant relationships between hTERT level and age groups or adenocarcinoma type among cases. Conclusions: The elevated hTERT mRNA/ DNA plasma level among patients indicates the accuracy of the proposed subjects. However, performing cohort studies on circulating hTERT mRNA is advised.

Item Type:Conference or Workshop Item (Poster)
زبان سند : انگلیسی
نویسنده مسئول :سید سعید حسینی اصل
نویسنده اول :هما اخوان
Additional Information:Impact Factor (2017) 13.926 Indexed in: ISI, Scopus, Pubmed/Medline/ Index Medicus, CAB Abstracts , Current Contents /Clinical Medicine , EMBASE
کلیدواژه ها (انگلیسی):gastric cancer, dna, iran, plasma, rna, messenger
Subjects:QY Clinical Pathology
WI Digestive System
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:10590
Deposited By: Dr S Saied Hosseini-Asl
Deposited On:15 Jul 1397 16:15
Last Modified:15 Jul 1397 16:53

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