اثر مکمل لاکتولوز بر روی فلور میکروبی مدفوع بیماران با نارسائی مزمن کلیوی: یک کارآزمائی بالینی

طیبی خسروشاهی, حمید and حبیب زاده, افشین and نیک نفس, بهرام and قوطاسلو, رضا and یگانه سفیدان, فاطمه and قوجازاده, مرتضی and مقدس زاده, مجید and پرخیده, سحر (1395) اثر مکمل لاکتولوز بر روی فلور میکروبی مدفوع بیماران با نارسائی مزمن کلیوی: یک کارآزمائی بالینی. Journal of renal injury prevention ــ 5 (3). pp. 162-167. شاپا 2345-2781


Official URL: http://journalrip.com/Abstract/JRIP_20160825113635


The effect of lactulose supplementation on fecal microflora of patients with chronic kidney disease; a randomized clinical trial

English Abstract

Introduction: Lactulose is a prebiotic with bifidogenic and urea reduction effects. It can improve Bifidobacteria and Lactobacilli counts in healthy humans and it may possibly have similar effects in chronic kidney disease (CKD) patients. Objectives: To investigate the effect of lactulose on fecal microflora of patients with CKD. Patients and Methods: Thirty-two patients with stages 3 and 4 of CKD (43.8% male with mean age of 58.09±12.75 years) were randomly assigned to intervention (n=16) and control (n=16) groups. Patients in intervention group received 30 mm lactulose syrup three times a day for an 8-week period. Control group received placebo 30 mm three times a day. A fecal sample was obtained from all patients at the beginning and at the end of the study and Bifidobacteria and Lactobacilli was counted. Results: Creatinine (Cr) significantly decreased in intervention group (3.90±1.43 to 3.60±1.44, P=0.003) and increased in control group (3.87±2.08 to 4.11±1.99, P=0.03). Although Bifidobacterial and Lactobacilli counts were similar before intervention, they were significantly higher at the end of the study in lactulose group (P=0.01 and P=0.04, respectively). Lactulose led to significant increase in fecal Bifidobacterial counts (3.61±0.54 to 4.90±0.96, P<0.001) and Lactobacilli counts (2.79±1.00 to 3.87±1.13, P<0.001), while the change in placebo group was not significant. Conclusion: Lactulose administration will increase Bifidobacteria and Lactobacillus counts in patients with CKD.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :حمید طیبی خسروشاهی
نویسنده :افشین حبیب زاده
نویسنده مسئول :بهرام نیک نفس
Additional Information:Indexed in: ESCI
کلیدواژه ها (انگلیسی):Chronic kidney disease, Lactulose, Fecal microflora, Bifidobacteria, Lactobacilli
Subjects:WI Digestive System
WJ Urogenital System
Divisions:Faculty of Medicine > Department of Internal Medicine , Cardiology , Infectious
ID Code:10656
Deposited By: دکتر افشین حبیب زاده
Deposited On:26 Aug 1397 10:30
Last Modified:26 Aug 1397 10:30

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