هدف قرار دادن مسیر آپوپتوز میتوکندریایی توسط مهار کننده COX-2 سنتز شده در سلول های سرطانی

اقوامی, مریم and سلیمی, احمد and عشقی, پیمان and زارعی, محمد هادی and فرزانه, شبنم and ستاری, فاطمه and زرقی, افشین and پوراحمد, جلال (1397) هدف قرار دادن مسیر آپوپتوز میتوکندریایی توسط مهار کننده COX-2 سنتز شده در سلول های سرطانی. Future Medicinal Chemistry ــ online . pp. 1-14. شاپا 1756-8919

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Official URL: https://www.future-science.com/doi/10.4155/fmc-201...


Targeting the mitochondrial apoptosis pathway by a newly synthesized COX-2 inhibitor in pediatric ALL lymphocytes

English Abstract

Aim: Acute lymphoblastic leukemia (ALL) is known as a barely curable malignancy. Particular mutations involved in apoptosis may have a main role in the onset of ALL in the pediatric patients. It has been proven that cycloxygenase-2 is capable of impairing the apoptosis pathway through mitochondria in tumor cells. Methodology: In this study, we investigated selective toxicity of a newly synthesized chalconeferrocenyl derivative as a selective cycloxygenase-2 inhibitor in ALL and healthy B-lymphocytes, and also isolated mitochondria obtained from them. For this purpose, we evaluated the cellar parameters like viability, apoptosis/necrosis, caspase-3 activation and ATP content, and also mitochondrial parameters like mitochondrial membrane potential decline, reactive oxygen species formation, cytochrome C release and mitochondrial swelling. Conclusion: Our results implied that this compound can selectively induce cellular and mitochondrial toxicity in cancerous ALL B-lymphocytes and obtained mitochondria from them without any detrimental effects on healthy subjects.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مریم اقوامی
نویسنده اول :احمد سلیمی
نویسنده :شبنم فرزانه
نویسنده :فاطمه ستاری
نویسنده مسئول :افشین زرقی
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact Factor (2017)3.969 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts, EMBASE, پایان نامه
کلیدواژه ها (انگلیسی):Apoptosis, Cyclooxygenase-2 Selective Inhibitors, Mitochondria, Pediatric ALL
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
School of Pharmacy > Department of Pharmacology
ID Code:10671
Deposited By: دکتر احمد سلیمی
Deposited On:03 Aug 1397 12:20
Last Modified:03 Aug 1397 12:22

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