تجزیه و تحلیل اثرات سمیتی از بوسپیرون، سیتیزین و اولانزاپین بر لنفوسیت های خون انسان: مدل In Vitro

سلیمی, احمد and رازیان, مصلح and پوراحمد, جلال (1397) تجزیه و تحلیل اثرات سمیتی از بوسپیرون، سیتیزین و اولانزاپین بر لنفوسیت های خون انسان: مدل In Vitro. Current Clinical Pharmacology ــ 13 (2). pp. 120-127. شاپا 1574-8847


Official URL: http://www.eurekaselect.com/162196


Analysis of Toxicity Effects of Buspirone, Cetirizine and Olanzapine on Human Blood Lymphocytes: In Vitro Model

English Abstract

Background: The current study investigates the cytotoxicity mechanism of common drugs with piperazine ring such as cetirizine, olanzapine and buspirone on human lymphocytes. Methods: The viability of lymphocytes, reactive oxygen species (ROS) formation, mitochondrial membrane potential (MMP) collapse, lysosomal integrity, content of glutathione and lipid peroxidation was determined. Results: Buspirone and cetirizine showed more toxicity than olanzapine on human lymphocytes with an IC50 value of 200 µg/ml, after 6 h of incubation. Significant ROS formation, MMP collapse, lipid peroxidation, lysosomal damage and elevation of glutathione disulfide (GSSG) were observed in treated lymphocytes concentrations (4, 20, 40 µg/ml) of buspirone and cetirizine. Conclusion: Our results show the exposure of human lymphocytes with buspirone and cetirizine, which usually happens during the poisoning, triggers oxidative stress and organelle damages. Our study suggests that using antioxidants, mitochondrial and lysosomal protective agents can protect blood lymphocytes, from probable side effects of these highly consumed medications.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :احمد سلیمی
نویسنده مسئول :جلال پوراحمد
Additional Information:Indexed in: ESCI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service, EMBASE, ProQuest, Google Scholar, , EBSCO
کلیدواژه ها (انگلیسی):Cetirizine, olanzapine, buspirone, toxicity, mitochondria, lysosome
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
School of Pharmacy > Department of Pharmacology
ID Code:10672
Deposited By: دکتر احمد سلیمی
Deposited On:28 Jul 1397 11:22
Last Modified:28 Jul 1397 11:22

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