title

حفاظت از آسیب کبدی و کلیوی نانو ذرات اکسید منگنز - توسط ویتامین D

اشرفی حافظ, اصغر and ناصر زاده, پروانه and اشتری, خدیجه and مرتضویان, امیرمحمد and سلیمی, احمد (1397) حفاظت از آسیب کبدی و کلیوی نانو ذرات اکسید منگنز - توسط ویتامین D. Regulatory Toxicology and Pharmacology ــ 98 . pp. 240-244. شاپا 0273-2300

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Title

Protection of manganese oxide nanoparticles-induced liver and kidney damage by vitamin D

English Abstract

Metal nanoparticles (NPs) have been extensively used in industry as well as in biomedical application. Manganese oxide-nanoparticles (MnO2-NPs) one of these materials, have many applications. This study was designed to evaluate the protective role of vitamin D against MnO2-NPs -induced toxicity in the BALB c mice. These mice were randomly assigned to 4 (n = 10). In this study, MnO2-NPs (10 mg/kg), vitamin D (10 mg/kg) and MnO2-NPs plus vitamin D were administered interperitoneally once daily for 50 consecutive days. The liver and kidney functions, the levels of serum glucose, albumin (ALB), bilirubin (BIL) and total protein were studied. The results indicated that MnO2-NPs administration significantly decreased liver and kidney functions, and increased glucose and bilirubin serum levels compared to control group (P < 0.05). However, vitamin D administration significantly boosted liver and kidney functions, decreased glucose and bilirubin serum level compared to the group received MnO2-NPs (P < 0.05). It seems that vitamin D administration could protect the liver and kidney damage induced by MnO2-NPs. Probably, given the use of these nanoparticles as a contest agent in humans, having normal levels of vitamin D or receiving it at the time of the test can inhibit liver and kidney toxicity induced by MnO2-NPs.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :اصغر اشرفی حافظ
نویسنده :پروانه ناصر زاده
نویسنده :خدیجه اشتری
نویسنده مسئول :امیرمحمد مرتضویان
نویسنده مسئول :احمد سلیمی
Additional Information:Impact factor (2017) 2.815 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, EMBASE, EMBiology
کلیدواژه ها (انگلیسی):Vitamin D, Liver, Kidney, Nanoparticles , Manganese oxide-nanoparticles
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
School of Pharmacy > Department of Pharmacology
ID Code:10675
Deposited By: دکتر احمد سلیمی
Deposited On:29 Jul 1397 12:13
Last Modified:29 Jul 1397 12:13

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