بررسی اثرات سمی فیبرین ابریشم بر روی لنفوسیت های و مونوسیت هاانسانی

ناصر زاده, پروانه and مرتضوی, سید علیرضا and اشتری, خدیجه and سلیمی, احمد and فرخی, مهدی and پوراحمد, جلال (1397) بررسی اثرات سمی فیبرین ابریشم بر روی لنفوسیت های و مونوسیت هاانسانی. Journal of Biochemical and Molecular Toxicology ــ 32 (6). pp. 1-7. شاپا 1095-6670

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Official URL: https://onlinelibrary.wiley.com/doi/10.1002/jbt.22...


Evaluation of the toxicity effects of silk fibroin on human lymphocytes and monocytes

English Abstract

Silk fibroin nanoparticles (SFNPs) as a natural polymer have been utilized in biomedical applications such as suture, tissue engineering-based scaffolds, and drug delivery carriers. Since there is little data regarding the toxicity effects on different cells and tissues, we aimed to determine the toxicity mechanisms of SFNPs on human lymphocytes and monocytes based on reliable methods. Our results showed that SFNPs (0.5, 1, and 2 mg/mL) induced oxidative stress via increasing reactive oxygen species production, mitochondrial membrane potential (∆Ψ) collapse, which was correlated to cytochrome c release and Adenosine diphosphate (ADP)/Adenosine tri phosphate (ATP) ratio increase as well as lysosomal as another toxicity mechanism, which led to cytosolic release of lysosomal digestive proteases, phosphor lipases, and apoptosis signaling. Taken together, these data suggested that SFNPs toxicity was associated with mutual mitochondrial/lysosomal cross-talk and oxidative stress on human lymphocytes and monocytes with activated apoptosis signaling.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :پروانه ناصر زاده
نویسنده :سید علیرضا مرتضوی
نویسنده :خدیجه اشتری
نویسنده :احمد سلیمی
نویسنده مسئول :مهدی فرخی
نویسنده مسئول :جلال پوراحمد
Additional Information:Impact factor (2017) 1.837 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus, Chemical Abstracts Service , Embase, Agricultural & Environmental Science Database (ProQuest), BIOBASE: پایان نامه
کلیدواژه ها (انگلیسی):lysosomal damage, membrane potential collapse, ROS formation, silk fibroin nanoparticles
Subjects:QV pharmacology > QV 600 Toxicology
QV pharmacology
Divisions:School of Pharmacy > Department of Toxicology
ID Code:10676
Deposited By: دکتر احمد سلیمی
Deposited On:06 Aug 1397 09:59
Last Modified:06 Aug 1397 09:59

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