title

اثر ترمیمی ویتامین E بر برخی پارامترهای ایمونولوژیکی موشهای سوری تابش دیده با اشعه گاما در دزهای زیر مرگ زا

کبودانیان اردستانی, سوسن and امانی, مجتبی and کریمی نیا, آمینا (1379) اثر ترمیمی ویتامین E بر برخی پارامترهای ایمونولوژیکی موشهای سوری تابش دیده با اشعه گاما در دزهای زیر مرگ زا. Iranian Biomedical Journal ــ 4 (1). pp. 51-55. شاپا 1028-852X

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Title

Restorative effect of vitamin E on some immunological parameters of sub-lethal g-irradiated BALB/c mice

English Abstract

Elevated amount of the free radicals due to ionizing radiation causes deteriorating damage on immune system. Therefore, we made attempts to investigate the protective effect of vitamin E (vit-E), a biological antioxidant in BALB/c mice, so as to find an affordable prophylactic supplementation for individuals who are at risk. Several groups of mice were selected and exposed to sub-lethal g-irradiation with or without vit-E supplementation. At the end of exposure, mice were immunized by either live attenuated Brucella melitensis vaccine or sheep red blood cell (SRBC). Consequently, the following parameters were assayed: specific antibody response, delayed type hypersensitivity and lymphocyte proliferation. We showed that vit-E supplementation restored the immune response in g-irradiated mice. These findings might have implications for individuals who are at risk of exposure to ionizing radiation.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :سوسن کبودانیان اردستانی
نویسنده :مجتبی امانی
Additional Information:indexing: scopus
Subjects:QW Microbiology and Immunology
WN Radiology . Diagnostic Imaging
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Biophysics
ID Code:1071
Deposited By: MS Soghra Golmaghani
Deposited On:13 Dec 1388 07:50
Last Modified:25 May 1397 08:42

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