بررسی فراوانی پلی مورفیسم های ژن TGF-B در جمعییت نرمال جنوب ایران

امانی, داور and فرجادیان, شیرین and قادری, عباس (1387) بررسی فراوانی پلی مورفیسم های ژن TGF-B در جمعییت نرمال جنوب ایران. International Journal of Immunogenetics ــ 35 (2). pp. 145-151. شاپا 1744-3121

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The frequency of transforming growth factor-TGF-B gene polymorphisms in a normal southern Iranian population

English Abstract

Several single nucleotide polymorphisms (SNPs) of the transforming growth factor-β1 gene (TGFB1) have been reported. Determination of TGFB1 SNPs allele frequencies in different ethnic groups is useful for both population genetic analyses and association studies with immunological diseases. In this study, five SNPs of TGFB1 were determined in 325 individuals from a normal southern Iranian population using polymerase chain reaction-restriction fragment length polymorphism method. This population was in Hardy-Weinberg equilibrium for these SNPs. Of the 12 constructed haplotypes, GTCGC and GCTGC were the most frequent in the normal southern Iranian population. Comparison of genotype and allele frequencies of TGFB SNPs between Iranian and other populations (meta-analysis) showed significant differences, and in this case the southern Iranian population seems genetically similar to Caucasoid populations. However, neighbour-joining tree using Nei's genetic distances based on TGF-β1 allele frequencies showed that southern Iranians are genetically far from people from the USA, Germany, UK, Denmark and the Czech Republic. In conclusion, this is the first report of the distribution of TGFB1 SNPs in an Iranian population and the results of this investigation may provide useful information for both population genetic and disease studies. © 2008 The Authors.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :داور امانی
Additional Information:cited By (since 1996) 1 Impact Factor:1.16 Indexed / Abstracted in:1-ISI,Medline/pubmed 2-Scopus,Current Contents 3-Academic Search (EBSCO),Academic Search Elite (EBSCO) Academic Search Premier (EBSCO),BIOBASE (Elsevier) CABI,CSA Biological Sciences Database (CSA/CIG) CSA Immunological Abstracts (CSA/CIG),Current Abstracts (EBSCO),Embase/Excerpta medica (Elsevier),Embiology (Elsevier),Health Source Nursing Academic,InfoTrac,Veterinary Bulletin (CABI/
کلیدواژه ها (انگلیسی):transforming growth factor beta1, adolescent; adult; aged; allele; article; Caucasian; controlled study; Czech Republic; Denmark; ethnic difference; female; gene frequency; gene linkage disequilibrium; genetic analysis; genetic association; genetic polymorphism; genotype; Germany; human; Iran; major clinical study; male; normal human; polymerase chain reaction; population genetics; priority journal; restriction fragment length polymorphism; single nucleotide polymorphism; United Kingdom; United States, Adolescent; Adult; Aged; Female; Gene Frequency; Genotype; Humans; Immune System Diseases; Iran; Male; Middle Aged; Polymorphism, Restriction Fragment Length; Polymorphism, Single Nucleotide; Transforming Growth Factor beta1
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:1075
Deposited By: Dr Davar Amani
Deposited On:14 Dec 1388 06:13
Last Modified:07 Jul 1393 05:02

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