نعیمی, سیروس ، فتوحی قیام, علی رضا ، مجتهدی, زهرا ، صمصامی دهقان, عالم تاج ، امانی, داور ، قادری, عباس (1385) بررسی پلی مورفیسم های ناحیه پروموتر ژن اینتر لوکین IL-18 و سقط مکرر خود به خود. European Journal of Obstetrics Gynecology and Reproductive Biology ــ 128 (1-2). ص.ص.5-9. شاپا 0301-2115
متن کامل
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متنی
- نسخه چاپ شده
52kB | |
متنی
- نسخه چاپ شده
محدود به فقط پرسنل سامانه 116kB |
آدرس اینترنتی رسمی : http://www.scopus.com/inward/record.url?eid=2-s2.0...
عنوان انگليسی
Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion
خلاصه انگلیسی
Background: IL-18 is a multifunctional cytokine capable of inducing either Th1 or Th2 polarization depending on the immunologic milieu. IL-18 is detected at the materno-fetal interface very soon in early pregnancy. Two polymorphisms in the promoter region of the IL-18 gene at positions of -607 and -137 appear to have functional impacts. Objective: This study attempts to evaluate the frequency of these two polymorphisms in the IL-18 gene promoter in patients with recurrent spontaneous abortion (RSA) and normal pregnant women. Subjects and methods: One hundred and two RSA patients and 103 healthy pregnant women were enrolled in this study. Single nucleotide polymorphisms of the IL-18 gene at positions -607 (C/A) and -137 (G/C) were analyzed by the sequence-specific PCR method. Results: There was no significant association between the allele, genotype, and haplotype frequencies of the two single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter and RSA. Conclusion: The results of this study showed that IL-18 gene promoter polymorphisms at positions -607 and -137 did not confer susceptibility to RSA in southern Iranian patients. © 2006 Elsevier Ireland Ltd. All rights reserved.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | سیروس نعیمی |
نویسنده مسئول : | عباس قادری |
ضریب تاثیر و نمایه مجلات: | cited By (since 1996) 5 |
کلیدواژه ها (انگلیسی): | amino acid; interleukin 18, adult; allele; amino acid substitution; article; controlled study; evaluation; female; gene frequency; gene location; genetic analysis; genetic polymorphism; genetic susceptibility; genotype; haplotype; human; Iran; major clinical study; polymerase chain reaction; pregnant woman; priority journal; promoter region; recurrent abortion; sample size; sequence analysis; single nucleotide polymorphism; spontaneous abortion, Abortion, Spontaneous; Adolescent; Adult; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Interleukin-18; Polymorphism, Genetic; Pregnancy; Promoter Regions (Genetics); Recurrence |
موضوعات : | WP بیماریهای زنان WQ مامایی QW میکروب شناسی و ایمنی شناسی |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش ايمنولوژی |
کد شناسایی : | 1076 |
ارائه شده توسط : | دکتر داور امانی |
ارائه شده در تاریخ : | 14 اسفند 1388 05:47 |
آخرین تغییر : | 07 مهر 1393 05:04 |
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