title

بررسی پلی مورفیسم های ناحیه پروموتر ژن اینتر لوکین IL-18 و سقط مکرر خود به خود

نعیمی, سیروس and فتوحی قیام, علی رضا and مجتهدی, زهرا and صمصامی دهقان, عالم تاج and امانی, داور and قادری, عباس (1385) بررسی پلی مورفیسم های ناحیه پروموتر ژن اینتر لوکین IL-18 و سقط مکرر خود به خود. European Journal of Obstetrics Gynecology and Reproductive Biology ــ 128 (1-2). pp. 5-9. شاپا 0301-2115

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Title

Interleukin-18 gene promoter polymorphisms and recurrent spontaneous abortion

English Abstract

Background: IL-18 is a multifunctional cytokine capable of inducing either Th1 or Th2 polarization depending on the immunologic milieu. IL-18 is detected at the materno-fetal interface very soon in early pregnancy. Two polymorphisms in the promoter region of the IL-18 gene at positions of -607 and -137 appear to have functional impacts. Objective: This study attempts to evaluate the frequency of these two polymorphisms in the IL-18 gene promoter in patients with recurrent spontaneous abortion (RSA) and normal pregnant women. Subjects and methods: One hundred and two RSA patients and 103 healthy pregnant women were enrolled in this study. Single nucleotide polymorphisms of the IL-18 gene at positions -607 (C/A) and -137 (G/C) were analyzed by the sequence-specific PCR method. Results: There was no significant association between the allele, genotype, and haplotype frequencies of the two single nucleotide polymorphisms (SNPs) in the IL-18 gene promoter and RSA. Conclusion: The results of this study showed that IL-18 gene promoter polymorphisms at positions -607 and -137 did not confer susceptibility to RSA in southern Iranian patients. © 2006 Elsevier Ireland Ltd. All rights reserved.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :سیروس نعیمی
نویسنده مسئول :عباس قادری
Additional Information:cited By (since 1996) 5
کلیدواژه ها (انگلیسی):amino acid; interleukin 18, adult; allele; amino acid substitution; article; controlled study; evaluation; female; gene frequency; gene location; genetic analysis; genetic polymorphism; genetic susceptibility; genotype; haplotype; human; Iran; major clinical study; polymerase chain reaction; pregnant woman; priority journal; promoter region; recurrent abortion; sample size; sequence analysis; single nucleotide polymorphism; spontaneous abortion, Abortion, Spontaneous; Adolescent; Adult; Case-Control Studies; Female; Genetic Predisposition to Disease; Humans; Interleukin-18; Polymorphism, Genetic; Pregnancy; Promoter Regions (Genetics); Recurrence
Subjects:WP Gynecology
WQ Obstetrics
QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:1076
Deposited By: Dr Davar Amani
Deposited On:14 Dec 1388 05:47
Last Modified:07 Jul 1393 05:04

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