بررسی ارتباط پلی مورفیسم های ناحیه پروموتر ژن TGF-B با سقط مکرر خود به خود

امانی, داور and ذوالقدری, ژاله and صمصامی دهقان, عالم تاج and پزشکی, عبدالمحمد and قادری, عباس (1383) بررسی ارتباط پلی مورفیسم های ناحیه پروموتر ژن TGF-B با سقط مکرر خود به خود. Journal of Reproductive Immunology ــ 62 (1-2). pp. 159-166. شاپا 0165-0378

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The promoter region (-800, -509) polymorphisms of transforming growth factor-β1 (TGF-β1) gene and recurrent spontaneous abortion

English Abstract

Recurrent spontaneous abortion (RSA) is regarded as a common pregnancy complication in southern Iran. The exact causes of RSA are not yet known. Transforming growth factor-β1 (TGF-β1) is produced by T regulatory lymphocytes (Treg), which play an important role in the physiology of pregnancy. Several polymorphisms of the TGF-β1 gene have been reported, some with important correlation with disease severity. In this investigation, the polymorphism of the TGF-β1 gene at promoter region positions -800 (G/A) and -509 (C/T) was studied in 111 RSA and 110 normal female subjects from southern Iran by PCR-RFLP. Results indicated that at position -800 (G/A) polymorphism, 75.7% of RSA cases and 77.3% of normals were homozygote GG. In addition, 23.4% of cases and 22.7% of normal individuals were heterozygote AG. Only one of the patients appeared to be homozygote AA. None of the normal individuals were found to be homozygote AA at this position. In the case of the -509 (C/T) polymorphism, 38.7% of patients and 28.2% of controls were homozygote CC. While 40.6% of cases and 50.9% of normal individuals were heterozygote CT, 20.7% of RSA cases and 20.9% of controls were homozygote TT. The results indicate that there are no statistically significant differences of genotype distribution and allele frequency between RSA cases and controls at both polymorphic sites. In conclusion, the promoter region polymorphisms of TGF-β1 at positions -800 (G/A) and -509 (C/T) may not be associated with RSA. © 2004 Elsevier Ireland Ltd. All rights reserved.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :داور امانی
نویسنده مسئول :عباس قادری
Additional Information:cited By (since 1996) 4
کلیدواژه ها (انگلیسی):transforming growth factor beta1, adolescent; adult; conference paper; controlled study; female; genetic polymorphism; heterozygosity; homozygosity; human; major clinical study; polymerase chain reaction; priority journal; promoter region; recurrent abortion; restriction fragment length polymorphism; Southern blotting; spontaneous abortion; statistical significance, Abortion, Habitual; Adolescent; Adult; Female; Gene Frequency; Humans; Polymorphism, Restriction Fragment Length; Pregnancy; Promoter Regions (Genetics); Transforming Growth Factor beta; Transforming Growth Factor beta1
Subjects:QW Microbiology and Immunology
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Immunology
ID Code:1078
Deposited By: Dr Davar Amani
Deposited On:13 Dec 1388 13:04
Last Modified:07 Jul 1393 05:06

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