مقایسه تکنیک های تجزیه و تحلیل گسترده ژنوم برای بررسی متیلاسیون DNA در سرطان های انسانی

سوزن گر, نرگس and محمد رضا, صادقی and جدی, فرهاد and صومی, محمدحسین and شیرمحمدی, مسعود and صمدی, ناصر (1397) مقایسه تکنیک های تجزیه و تحلیل گسترده ژنوم برای بررسی متیلاسیون DNA در سرطان های انسانی. Journal of Cellular Physiology ــ 233 (5). pp. 3968-3981. شاپا 0021-9541

[img] Text
محدود به Repository staff only


Official URL: https://onlinelibrary.wiley.com/doi/10.1002/jcp.26...


Comparison of genome‐wide analysis techniques to DNA methylation analysis in human cancer

English Abstract

DNA methylation was the first epigenetic modification to be detected in human cancers with specific relation to aberrant gene expression. Herein, DNA methylation analysis explains how epigenetic patterns affect gene expression level. Hypermethylation at tumor suppressor gene loci leads to increased tumorigenesis due to tumor suppressor gene silencing, whereas global hypomethylation of CpG islands (CGIs) is followed by genomic instability and aberrant activation of multiple oncogenes. Therefore, characterization of the genes which silenced or activated epigenetically in human tumor cells can improve our understanding of cancer biology. Different genome‐wide methodologies are applied to evaluate methylation status. Various commonly conducted techniques for this evaluation are reviewed in this paper. We provided comparative description of the procedures, advantages, and drawbacks of genome‐wide DNA methylation analysis methods and biological applications, to give information on selecting the appropriate method for different methylation studies.

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :نرگس سوزن گر
نویسنده :صادقی محمد رضا
نویسنده :فرهاد جدی
نویسنده مسئول :ناصر صمدی
Additional Information:Impact Factor (2017) 3.923 Indexed in: ISI, Pubmed/Medlin/Index Medicus, Scopus, Chemical Abstracts Service, Embase, Abstracts on Hygiene & Communicable Diseases, Agricultural & Environmental Science Database, BIOBASE: Current Awareness in Biological Sciences
کلیدواژه ها (انگلیسی):cancer, DNA methylation, epigenetic, genome-wide analysis
Subjects:QT physiology
QU Biochemistry
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:10836
Deposited By: Dr. Farhad Jeddi
Deposited On:06 Sep 1397 09:35
Last Modified:10 Apr 1398 10:06

Repository Staff Only: item control page

Document Downloads

More statistics for this item...