سنتز بیومیمتیک نانوذرات نقره با استفاده از عصاره بابونه آلمانی و فعالیت ضد سرطانی بالقوه آنها در برابر سلول های سرطانی ریه انسان

داداش پور, مهدی and فیروزی امندی, اکرم and پورحسن مقدم, محمد and ملکی, محمدجعفر and سوزن گر, نرگس and جدی, فرهاد and نوری, محمد and ضرغامی, نصرت الله and پیله ورسلطان احمدی, یونس (1397) سنتز بیومیمتیک نانوذرات نقره با استفاده از عصاره بابونه آلمانی و فعالیت ضد سرطانی بالقوه آنها در برابر سلول های سرطانی ریه انسان. Materials Science & Engineering: C ــ 92 . pp. 902-912. شاپا 0928-4931

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Biomimetic synthesis of silver nanoparticles usingMatricaria chamomilla extract and their potential anticancer activity against human lung cancer cells

English Abstract

Herbs having various natural substances can be utilized for the biosynthesis of Silver nanoparticles (AgNPs) and act as a stable, reliable and biocompatible alternative instead of the current physical and chemical approaches. It has been reported that Matricaria chamomilla possesses unique properties, especially anti-cancerous effects. The objective of the current work was to assess the chemical characteristics and anticancer effects of biosynthesized AgNPs applying aqueous extracts of M. chamomilla against A549 lung cancer cells. UV–visible spectrum showed the maximum absorption of the biosynthesized AgNPs at 430 nm. The crystalline structure of biosynthesized AgNPs in optimal conditions was confirmed by XRD. Moreover, the presence of Ag as the ingredient element was exhibited via EDX analysis. FT-IR results also verified the AgNPs synthesis using a plant extract. The spherical shapes of the AgNPs with an average diameter size around 45.12 nm and a zeta potential value of−34 mV were characterized using DLS, and confirmed through FE-SEM and TEM. In vitro cytotoxicity assay using MTT revealed that the biosynthesized AgNPs exhibited a dose- and time- dependent cytotoxic effect against A549 lung cancer cells. Moreover, the apoptotic effects of the AgNPs were demonstrated using DAPI staining, real-time PCR and flow cytometry. According to these findings, using M. chamomilla in combination with AgNPs via green synthesis approach may be an efficient strategy for effective treatment of lung cancer

Item Type:Article
زبان سند : انگلیسی
نویسنده اول :مهدی داداش پور
نویسنده :اکرم فیروزی امندی
نویسنده :محمد پورحسن مقدم
نویسنده :محمدجعفر ملکی
نویسنده :نرگس سوزن گر
نویسنده :فرهاد جدی
نویسنده :محمد نوری
نویسنده :نصرت الله ضرغامی
نویسنده مسئول :یونس پیله ورسلطان احمدی
Additional Information:Impact Factor (2017) 5.08 Indexed in: ISI, Pubmed/Medline/Index Medicus, Scopus
کلیدواژه ها (انگلیسی):Matricaria chamomilla , AgNPs , Green synthesis , Lung cancer
Subjects:QV pharmacology > QV 737 Pharmaceutical Biotechnology
QV pharmacology > QV 778 Pharmaceutical Nanotechnology
QY Clinical Pathology
QV pharmacology > QV 766 Plants, Medicinal
Divisions:Faculty of Medicine > Department of Basic Sciences > Department of Genetics
ID Code:10839
Deposited By: Dr. Farhad Jeddi
Deposited On:06 Sep 1397 13:20
Last Modified:06 Sep 1397 15:16

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